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- W2081103456 abstract "Background: Amyloidosis consisting of extracellular deposits of immunoglobulin light chains (AL) is an uncommon plasma cell dyscrasia and the prognosis is poor. Approximately 20% of patients with AL have multiple myeloma. Amyloid deposition occurs frequently at any level of the gastrointestinal tract. Case Reports: We attended 4 patients with AL and multiple myeloma showing symptomatic amyloid involvement of the upper gastrointestinal tract with macroglossia, enlarged salivary glands, xerostomia, dysphagia, achalasia, gastroparesis, diarrhea, ulceration, and fistula of the stomach. All of our patients had urinary light chain excretion, often associated with amyloidosis. There is no effective therapy that can predictably reverse the process of amyloid deposition. In our patients receiving colchicine/prednisone, melphalan/prednisone, or aggressive chemotherapy, all parameters of multiple myeloma were at least temporarily regressive, while clinical manifestations of AL were more or less continuously progressive. The patients died 7, 30, 36, and 59 months after the onset of myeloma-associated amyloidosis, due to amyloid-related heart failure or lung embolism. Conclusions: New treatment options for patients with AL are necessary. Hopeful attempts seem to be the anthracycline iododeoxydoxorubicin and high-dose melphalan with autologous blood stem cell support." @default.
- W2081103456 created "2016-06-24" @default.
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- W2081103456 date "1999-01-01" @default.
- W2081103456 modified "2023-10-16" @default.
- W2081103456 title "Myeloma-Associated Amyloidosis of the Upper Gastrointestinal Tract" @default.
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- W2081103456 doi "https://doi.org/10.1159/000027029" @default.
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