FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081103640> ?p ?o ?g. }

• W2081103640 endingPage "272" @default.
• W2081103640 startingPage "267" @default.
• W2081103640 abstract "Toll-like receptors (TLRs) recognize pathogens and their components, thereby initiating immune responses to infectious organisms. TLR ligation leads to the activation of NF-κB and MAPKs through well-defined pathways, but it has remained unclear how TLR signaling activates PI3K, which provides an inhibitory pathway limiting TLR responses. Here, we show that the signaling adapter B-cell adaptor for PI3K (BCAP) links TLR signaling to PI3K activation. BCAP-deficient macrophages and mice are hyperresponsive to TLR agonists and have reduced PI3K activation. The ability of BCAP to inhibit TLR responses requires its capacity to bind PI3K. BCAP is constitutively phosphorylated and associated with the p85 subunit of PI3K in macrophages. This tyrosine-phosphorylated BCAP is transiently enriched in the membrane fraction in response to LPS treatment, suggesting a model whereby TLR signaling causes the phosphorylation of the small amount of BCAP that is associated with membranes in the resting state or the translocation of phosphorylated BCAP from the cytoplasm to the membrane. This accumulation of tyrosine-phosphorylated BCAP at the membrane with its associated PI3K would then allow for the catalysis of Ptd Ins P2 to Ptd Ins P3 and downstream PI3K-dependent signals. Therefore, BCAP is an essential activator of the PI3K pathway downstream of TLR signaling, providing a brake to limit potentially pathogenic excessive TLR responses." @default.
• W2081103640 created "2016-06-24" @default.
• W2081103640 creator A5021144595 @default.
• W2081103640 creator A5036296799 @default.
• W2081103640 creator A5075685028 @default.
• W2081103640 creator A5079510865 @default.
• W2081103640 creator A5082818365 @default.
• W2081103640 creator A5090058337 @default.
• W2081103640 date "2011-12-20" @default.
• W2081103640 modified "2023-10-18" @default.
• W2081103640 title "B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K" @default.
• W2081103640 cites W10482017 @default.
• W2081103640 cites W1965471441 @default.
• W2081103640 cites W1980547319 @default.
• W2081103640 cites W2008488946 @default.
• W2081103640 cites W2009886463 @default.
• W2081103640 cites W2010817360 @default.
• W2081103640 cites W2019209562 @default.
• W2081103640 cites W2025234369 @default.
• W2081103640 cites W2048236539 @default.
• W2081103640 cites W2050069950 @default.
• W2081103640 cites W2060309429 @default.
• W2081103640 cites W2063595818 @default.
• W2081103640 cites W2069089745 @default.
• W2081103640 cites W2070065676 @default.
• W2081103640 cites W2070732456 @default.
• W2081103640 cites W2080503511 @default.
• W2081103640 cites W2086676303 @default.
• W2081103640 cites W2089360911 @default.
• W2081103640 cites W2091836237 @default.
• W2081103640 cites W2094068658 @default.
• W2081103640 cites W2106684817 @default.
• W2081103640 cites W2109491705 @default.
• W2081103640 cites W2120211786 @default.
• W2081103640 cites W2135701801 @default.
• W2081103640 cites W2144675149 @default.
• W2081103640 cites W2157429934 @default.
• W2081103640 cites W2170966854 @default.
• W2081103640 cites W27857866 @default.
• W2081103640 doi "https://doi.org/10.1073/pnas.1111957108" @default.
• W2081103640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3252908" @default.
• W2081103640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22187458" @default.
• W2081103640 hasPublicationYear "2011" @default.
• W2081103640 type Work @default.
• W2081103640 sameAs 2081103640 @default.
• W2081103640 citedByCount "71" @default.
• W2081103640 countsByYear W20811036402012 @default.
• W2081103640 countsByYear W20811036402013 @default.
• W2081103640 countsByYear W20811036402014 @default.
• W2081103640 countsByYear W20811036402015 @default.
• W2081103640 countsByYear W20811036402016 @default.
• W2081103640 countsByYear W20811036402017 @default.
• W2081103640 countsByYear W20811036402018 @default.
• W2081103640 countsByYear W20811036402019 @default.
• W2081103640 countsByYear W20811036402020 @default.
• W2081103640 countsByYear W20811036402021 @default.
• W2081103640 countsByYear W20811036402022 @default.
• W2081103640 crossrefType "journal-article" @default.
• W2081103640 hasAuthorship W2081103640A5021144595 @default.
• W2081103640 hasAuthorship W2081103640A5036296799 @default.
• W2081103640 hasAuthorship W2081103640A5075685028 @default.
• W2081103640 hasAuthorship W2081103640A5079510865 @default.
• W2081103640 hasAuthorship W2081103640A5082818365 @default.
• W2081103640 hasAuthorship W2081103640A5090058337 @default.
• W2081103640 hasBestOaLocation W20811036401 @default.
• W2081103640 hasConcept C11960822 @default.
• W2081103640 hasConcept C136449434 @default.
• W2081103640 hasConcept C170493617 @default.
• W2081103640 hasConcept C185592680 @default.
• W2081103640 hasConcept C2776709828 @default.
• W2081103640 hasConcept C2777553839 @default.
• W2081103640 hasConcept C2781322055 @default.
• W2081103640 hasConcept C55493867 @default.
• W2081103640 hasConcept C62478195 @default.
• W2081103640 hasConcept C86554907 @default.
• W2081103640 hasConcept C86803240 @default.
• W2081103640 hasConcept C95444343 @default.
• W2081103640 hasConceptScore W2081103640C11960822 @default.
• W2081103640 hasConceptScore W2081103640C136449434 @default.
• W2081103640 hasConceptScore W2081103640C170493617 @default.
• W2081103640 hasConceptScore W2081103640C185592680 @default.
• W2081103640 hasConceptScore W2081103640C2776709828 @default.
• W2081103640 hasConceptScore W2081103640C2777553839 @default.
• W2081103640 hasConceptScore W2081103640C2781322055 @default.
• W2081103640 hasConceptScore W2081103640C55493867 @default.
• W2081103640 hasConceptScore W2081103640C62478195 @default.
• W2081103640 hasConceptScore W2081103640C86554907 @default.
• W2081103640 hasConceptScore W2081103640C86803240 @default.
• W2081103640 hasConceptScore W2081103640C95444343 @default.
• W2081103640 hasIssue "1" @default.
• W2081103640 hasLocation W20811036401 @default.
• W2081103640 hasLocation W20811036402 @default.
• W2081103640 hasLocation W20811036403 @default.
• W2081103640 hasLocation W20811036404 @default.
• W2081103640 hasOpenAccess W2081103640 @default.
• W2081103640 hasPrimaryLocation W20811036401 @default.
• W2081103640 hasRelatedWork W1531825933 @default.
• W2081103640 hasRelatedWork W1965594477 @default.

• next