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- W2081103693 abstract "Abstract The chronic administration of phenylethylamine (50 mg/kg) or d-amphetamine (3.75 mg/kg) produces stereotyped behavior in rats. This chronic administration induces a behavioral sensitization consisting of an increase in intensity of stereotypies and a decrease in their latency to onset. The substitution of phenylethylamine for d-amphetamine, or vice versa, maintains not only stereotypies but also the sensitization effect. Acute pretreatments with the anti-psychotic dopamine blockers haloperidol and pimozide block stereotypy induced by both phenylethylamine and d-amphetamine, whereas antipsychotics with fewer extrapyramidal effects, thioridazine and clozapine, preferentially block phenylethylamine-evoked behavior. The fact that stereotypy induced by phenylethylamine, unlike that induced by d-amphetamine, does not depend so greatly upon neostriatal actions suggests that it may therefore represent a better animal model for schizophrenia." @default.
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- W2081103693 date "1977-07-01" @default.
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- W2081103693 title "Chronic phenylethylamine stereotypy in rats: A new animal model for schizophrenia?" @default.
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- W2081103693 doi "https://doi.org/10.1016/0024-3205(77)90431-3" @default.
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