FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081122654> ?p ?o ?g. }

• W2081122654 endingPage "18" @default.
• W2081122654 startingPage "15" @default.
• W2081122654 abstract "Previous studies have indicated that methamphetamine (MA) potentiates neurodegeneration induced by ischemia in brain. We, and others, have reported that bone morphogenetic protein 7 (BMP7) is protective against MA and ischemic brain injury. The purpose of this study is to examine whether BMP7 reduces synergistic injury induced by both MA and cerebral ischemia. Adult CD-1 mice were treated with MA (4x 10mg/kg, each dose 2h apart) or saline. Using the quantitative real time polymerase chain reaction, we found that MA suppressed the expression of BMP7 mRNA in the cerebral cortex 1 day after injection. Ischemic and reperfusional injuries were introduced by ligation of the right middle cerebral artery for 90min after MA injection. Animals were sacrificed for caspase-3/7 activity assay and tri-phenyl-tetrazolium chloride staining at 1h and 2 days after reperfusion, respectively. Cerebral infarction and caspase-3/7 activity were enhanced in the stroke animals pretreated with MA; both responses were attenuated by pretreatment with BMP7. In conclusion, our data suggest that MA facilitates cerebral infarction after ischemia possibly mediated, in part, through the suppression of BMP7." @default.
• W2081122654 created "2016-06-24" @default.
• W2081122654 creator A5041567436 @default.
• W2081122654 creator A5064904136 @default.
• W2081122654 creator A5065178862 @default.
• W2081122654 creator A5089083214 @default.
• W2081122654 date "2008-09-01" @default.
• W2081122654 modified "2023-10-18" @default.
• W2081122654 title "BMP7 reduces synergistic injury induced by methamphetamine and ischemia in mouse brain" @default.
• W2081122654 cites W1972967680 @default.
• W2081122654 cites W1976632696 @default.
• W2081122654 cites W1982055485 @default.
• W2081122654 cites W1997670388 @default.
• W2081122654 cites W2022628636 @default.
• W2081122654 cites W2033543666 @default.
• W2081122654 cites W2042505270 @default.
• W2081122654 cites W2047284199 @default.
• W2081122654 cites W2051133334 @default.
• W2081122654 cites W2083351059 @default.
• W2081122654 cites W2096048016 @default.
• W2081122654 cites W2132895844 @default.
• W2081122654 cites W2136781825 @default.
• W2081122654 cites W2141898798 @default.
• W2081122654 cites W2142951448 @default.
• W2081122654 cites W2144739559 @default.
• W2081122654 cites W2156789300 @default.
• W2081122654 cites W2163098796 @default.
• W2081122654 doi "https://doi.org/10.1016/j.neulet.2008.06.052" @default.
• W2081122654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2493608" @default.
• W2081122654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18598737" @default.
• W2081122654 hasPublicationYear "2008" @default.
• W2081122654 type Work @default.
• W2081122654 sameAs 2081122654 @default.
• W2081122654 citedByCount "21" @default.
• W2081122654 countsByYear W20811226542013 @default.
• W2081122654 countsByYear W20811226542015 @default.
• W2081122654 countsByYear W20811226542016 @default.
• W2081122654 countsByYear W20811226542020 @default.
• W2081122654 countsByYear W20811226542021 @default.
• W2081122654 countsByYear W20811226542022 @default.
• W2081122654 crossrefType "journal-article" @default.
• W2081122654 hasAuthorship W2081122654A5041567436 @default.
• W2081122654 hasAuthorship W2081122654A5064904136 @default.
• W2081122654 hasAuthorship W2081122654A5065178862 @default.
• W2081122654 hasAuthorship W2081122654A5089083214 @default.
• W2081122654 hasBestOaLocation W20811226542 @default.
• W2081122654 hasConcept C104317684 @default.
• W2081122654 hasConcept C125349252 @default.
• W2081122654 hasConcept C126322002 @default.
• W2081122654 hasConcept C127413603 @default.
• W2081122654 hasConcept C179437574 @default.
• W2081122654 hasConcept C185592680 @default.
• W2081122654 hasConcept C2777798775 @default.
• W2081122654 hasConcept C2778820722 @default.
• W2081122654 hasConcept C2779450755 @default.
• W2081122654 hasConcept C2780376393 @default.
• W2081122654 hasConcept C2780645631 @default.
• W2081122654 hasConcept C31507581 @default.
• W2081122654 hasConcept C42219234 @default.
• W2081122654 hasConcept C500558357 @default.
• W2081122654 hasConcept C541997718 @default.
• W2081122654 hasConcept C55493867 @default.
• W2081122654 hasConcept C71924100 @default.
• W2081122654 hasConcept C78519656 @default.
• W2081122654 hasConcept C98274493 @default.
• W2081122654 hasConceptScore W2081122654C104317684 @default.
• W2081122654 hasConceptScore W2081122654C125349252 @default.
• W2081122654 hasConceptScore W2081122654C126322002 @default.
• W2081122654 hasConceptScore W2081122654C127413603 @default.
• W2081122654 hasConceptScore W2081122654C179437574 @default.
• W2081122654 hasConceptScore W2081122654C185592680 @default.
• W2081122654 hasConceptScore W2081122654C2777798775 @default.
• W2081122654 hasConceptScore W2081122654C2778820722 @default.
• W2081122654 hasConceptScore W2081122654C2779450755 @default.
• W2081122654 hasConceptScore W2081122654C2780376393 @default.
• W2081122654 hasConceptScore W2081122654C2780645631 @default.
• W2081122654 hasConceptScore W2081122654C31507581 @default.
• W2081122654 hasConceptScore W2081122654C42219234 @default.
• W2081122654 hasConceptScore W2081122654C500558357 @default.
• W2081122654 hasConceptScore W2081122654C541997718 @default.
• W2081122654 hasConceptScore W2081122654C55493867 @default.
• W2081122654 hasConceptScore W2081122654C71924100 @default.
• W2081122654 hasConceptScore W2081122654C78519656 @default.
• W2081122654 hasConceptScore W2081122654C98274493 @default.
• W2081122654 hasIssue "1" @default.
• W2081122654 hasLocation W20811226541 @default.
• W2081122654 hasLocation W20811226542 @default.
• W2081122654 hasLocation W20811226543 @default.
• W2081122654 hasLocation W20811226544 @default.
• W2081122654 hasOpenAccess W2081122654 @default.
• W2081122654 hasPrimaryLocation W20811226541 @default.
• W2081122654 hasRelatedWork W2029479814 @default.
• W2081122654 hasRelatedWork W2155698194 @default.
• W2081122654 hasRelatedWork W2262308730 @default.
• W2081122654 hasRelatedWork W2350050207 @default.
• W2081122654 hasRelatedWork W2364851793 @default.
• W2081122654 hasRelatedWork W2369481170 @default.
• W2081122654 hasRelatedWork W2371313106 @default.

• next