FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081124079> ?p ?o ?g. }

• W2081124079 endingPage "913" @default.
• W2081124079 startingPage "909" @default.
• W2081124079 abstract "Generation of alloantibodies to transfused RBCs can be a serious medical problem for patients who require chronic RBC transfusion therapy. Patients with sickle cell disease have a substantially increased rate of alloimmunization compared to other chronically transfused populations. A recent study has forwarded the hypothesis that a polymorphism in an immunoregulatory gene in close proximity to beta-globin (TRIM21 rs660) plays a role in the increased rates of RBC alloimmunization in sickle cell patients. In particular, it was hypothesized that rs660C/T decreases expression of TRIM21, resulting in loss of a negative feedback pathway in immune responses and increased RBC alloimmunization. To test the effects of TRIM21 expression on alloimmunization, we analyzed antibody responses to alloantigens on RBCs and platelets transfused into wild-type and TRIM21 KO mice. No significant increases were seen in the frequency or magnitude of humoral immunization to alloantigens on transfused RBCs or platelets in adult or juvenile TRIM21 KO recipients compared to wild-type controls. Moreover, recipient inflammation with poly (I:C) enhanced RBC alloimmunization to similar degrees in both TRIM21 KO and wild-type control recipients. Together, these data rule out the hypothesis that decreased TRIM21 expression enhances transfusion induced humoral alloimmunization, in the context of a reductionist murine model." @default.
• W2081124079 created "2016-06-24" @default.
• W2081124079 creator A5009363901 @default.
• W2081124079 creator A5015543981 @default.
• W2081124079 creator A5033861845 @default.
• W2081124079 creator A5041867277 @default.
• W2081124079 creator A5075025657 @default.
• W2081124079 creator A5079697346 @default.
• W2081124079 creator A5083730552 @default.
• W2081124079 creator A5091257614 @default.
• W2081124079 date "2011-03-01" @default.
• W2081124079 modified "2023-09-24" @default.
• W2081124079 title "Alloimmunization against RBC or PLT antigens is independent of TRIM21 expression in a murine model" @default.
• W2081124079 cites W145680385 @default.
• W2081124079 cites W1950598818 @default.
• W2081124079 cites W1976293536 @default.
• W2081124079 cites W2009558210 @default.
• W2081124079 cites W2031573639 @default.
• W2081124079 cites W2046365010 @default.
• W2081124079 cites W2059817933 @default.
• W2081124079 cites W2060519397 @default.
• W2081124079 cites W2113722701 @default.
• W2081124079 cites W2115169225 @default.
• W2081124079 cites W2122543047 @default.
• W2081124079 cites W2127003152 @default.
• W2081124079 cites W2145357113 @default.
• W2081124079 cites W2469456985 @default.
• W2081124079 cites W2993077556 @default.
• W2081124079 doi "https://doi.org/10.1016/j.molimm.2010.12.017" @default.
• W2081124079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3090620" @default.
• W2081124079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21269695" @default.
• W2081124079 hasPublicationYear "2011" @default.
• W2081124079 type Work @default.
• W2081124079 sameAs 2081124079 @default.
• W2081124079 citedByCount "9" @default.
• W2081124079 countsByYear W20811240792012 @default.
• W2081124079 countsByYear W20811240792014 @default.
• W2081124079 crossrefType "journal-article" @default.
• W2081124079 hasAuthorship W2081124079A5009363901 @default.
• W2081124079 hasAuthorship W2081124079A5015543981 @default.
• W2081124079 hasAuthorship W2081124079A5033861845 @default.
• W2081124079 hasAuthorship W2081124079A5041867277 @default.
• W2081124079 hasAuthorship W2081124079A5075025657 @default.
• W2081124079 hasAuthorship W2081124079A5079697346 @default.
• W2081124079 hasAuthorship W2081124079A5083730552 @default.
• W2081124079 hasAuthorship W2081124079A5091257614 @default.
• W2081124079 hasBestOaLocation W20811240792 @default.
• W2081124079 hasConcept C104317684 @default.
• W2081124079 hasConcept C143065580 @default.
• W2081124079 hasConcept C147483822 @default.
• W2081124079 hasConcept C151730666 @default.
• W2081124079 hasConcept C159654299 @default.
• W2081124079 hasConcept C203014093 @default.
• W2081124079 hasConcept C207583985 @default.
• W2081124079 hasConcept C2776914184 @default.
• W2081124079 hasConcept C2778430493 @default.
• W2081124079 hasConcept C2779343474 @default.
• W2081124079 hasConcept C2780801004 @default.
• W2081124079 hasConcept C54355233 @default.
• W2081124079 hasConcept C71924100 @default.
• W2081124079 hasConcept C86803240 @default.
• W2081124079 hasConcept C8891405 @default.
• W2081124079 hasConcept C89560881 @default.
• W2081124079 hasConceptScore W2081124079C104317684 @default.
• W2081124079 hasConceptScore W2081124079C143065580 @default.
• W2081124079 hasConceptScore W2081124079C147483822 @default.
• W2081124079 hasConceptScore W2081124079C151730666 @default.
• W2081124079 hasConceptScore W2081124079C159654299 @default.
• W2081124079 hasConceptScore W2081124079C203014093 @default.
• W2081124079 hasConceptScore W2081124079C207583985 @default.
• W2081124079 hasConceptScore W2081124079C2776914184 @default.
• W2081124079 hasConceptScore W2081124079C2778430493 @default.
• W2081124079 hasConceptScore W2081124079C2779343474 @default.
• W2081124079 hasConceptScore W2081124079C2780801004 @default.
• W2081124079 hasConceptScore W2081124079C54355233 @default.
• W2081124079 hasConceptScore W2081124079C71924100 @default.
• W2081124079 hasConceptScore W2081124079C86803240 @default.
• W2081124079 hasConceptScore W2081124079C8891405 @default.
• W2081124079 hasConceptScore W2081124079C89560881 @default.
• W2081124079 hasIssue "6-7" @default.
• W2081124079 hasLocation W20811240791 @default.
• W2081124079 hasLocation W20811240792 @default.
• W2081124079 hasLocation W20811240793 @default.
• W2081124079 hasLocation W20811240794 @default.
• W2081124079 hasOpenAccess W2081124079 @default.
• W2081124079 hasPrimaryLocation W20811240791 @default.
• W2081124079 hasRelatedWork W145680385 @default.
• W2081124079 hasRelatedWork W1976293536 @default.
• W2081124079 hasRelatedWork W1981552674 @default.
• W2081124079 hasRelatedWork W1995432147 @default.
• W2081124079 hasRelatedWork W2008874127 @default.
• W2081124079 hasRelatedWork W2031573639 @default.
• W2081124079 hasRelatedWork W2059817933 @default.
• W2081124079 hasRelatedWork W2091295579 @default.
• W2081124079 hasRelatedWork W2115169225 @default.
• W2081124079 hasRelatedWork W2122870143 @default.
• W2081124079 hasRelatedWork W2152078119 @default.
• W2081124079 hasRelatedWork W2167615059 @default.

• next