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• W2081134662 abstract "Objective: Over the last year, a controversial issue has existed about the equivalency of recombinant hCG 250mcg to u-hCG 10,000 IU. Even though initial investigational trials established the effectiveness of 250mcg r-hCG 1Chang, FS 76: 1, pp 67–74, 2001., 2Driscoll, HR 15: 6, pp 1305–1310, 2000., the objective of this analysis was to evaluate the treatment outcomes when u-hCG or r-hCG was used for ovulation triggering in ART patients following our typical protocols.Design: A single center, retrospective analysis comparing ART cycles undertaken between January and November 2002 in patients 26–42 years old who received hCG.Materials and Method: All patients (N=117) undergoing IVF or IVF/ISCI were screened to identify those receiving 250 mcg of Ovidrel (r-hCG) or 10,000 IU u-hCG prior to egg retrieval. The study group consisted of 37 patients in the r-hCG group and 36 in the u-hCG group who were pre-treated with mid-luteal GnRH-agonist as per our normal protocol. The remaining patients were eliminated due to receiving GnRH antagonists or cancellation prior to hCG administration. A statistical analysis for normality and a 95% two-sided confidence interval using STATPRO software confirmed normal distribution between the groups based on age, number of prior ART cycles, total dose FSH, total LH dose, peak estradiol (E2), and number of follicles > 15mm. A p value of 0.05 failed to show a statistically significant difference, except for the number of stimulation days, between the groups thus they were comparable for further analysis to determine if a difference existed in the outcomes based on the type of hCG administered.Results: No between-group differences were noted in the following outcome categories: age, # of prior ART attempts, FSH dose, peak E2, # of follicles > 15mm on the day of hCG, oocyte: follicle ratio, MII: follicle ratio, fertilization rate, # of 2PN oocytes, # of cleaved embryos or # of embryos transferred. Statistically significant differences existed for the mean number of oocytes retrieved and mean number of MII oocytes, as noted below. Empty follicle syndrome was not observed in either treatment group. Tabled 1Mean +SD using a 2-sided CI with p<0.05∗Only 18 and 19 patients for u-hCG and r-hCG, respectively had the number of MII oocytes noted.Conclusions: From these results, it is apparent that no difference exists between Ovidrel 250 mcg and 10,000 IU of u-hCG. Based on these results, our clinic believes Ovidrel is an effective and safe replacement for u-hCG 10,000 IU.1Chang, FS 76: 1, pp 67–74, 2001. 2Driscoll, HR 15: 6, pp 1305–1310, 2000. Objective: Over the last year, a controversial issue has existed about the equivalency of recombinant hCG 250mcg to u-hCG 10,000 IU. Even though initial investigational trials established the effectiveness of 250mcg r-hCG 1Chang, FS 76: 1, pp 67–74, 2001., 2Driscoll, HR 15: 6, pp 1305–1310, 2000., the objective of this analysis was to evaluate the treatment outcomes when u-hCG or r-hCG was used for ovulation triggering in ART patients following our typical protocols. Design: A single center, retrospective analysis comparing ART cycles undertaken between January and November 2002 in patients 26–42 years old who received hCG. Materials and Method: All patients (N=117) undergoing IVF or IVF/ISCI were screened to identify those receiving 250 mcg of Ovidrel (r-hCG) or 10,000 IU u-hCG prior to egg retrieval. The study group consisted of 37 patients in the r-hCG group and 36 in the u-hCG group who were pre-treated with mid-luteal GnRH-agonist as per our normal protocol. The remaining patients were eliminated due to receiving GnRH antagonists or cancellation prior to hCG administration. A statistical analysis for normality and a 95% two-sided confidence interval using STATPRO software confirmed normal distribution between the groups based on age, number of prior ART cycles, total dose FSH, total LH dose, peak estradiol (E2), and number of follicles > 15mm. A p value of 0.05 failed to show a statistically significant difference, except for the number of stimulation days, between the groups thus they were comparable for further analysis to determine if a difference existed in the outcomes based on the type of hCG administered. Results: No between-group differences were noted in the following outcome categories: age, # of prior ART attempts, FSH dose, peak E2, # of follicles > 15mm on the day of hCG, oocyte: follicle ratio, MII: follicle ratio, fertilization rate, # of 2PN oocytes, # of cleaved embryos or # of embryos transferred. Statistically significant differences existed for the mean number of oocytes retrieved and mean number of MII oocytes, as noted below. Empty follicle syndrome was not observed in either treatment group. Tabled 1Mean +SD using a 2-sided CI with p<0.05∗Only 18 and 19 patients for u-hCG and r-hCG, respectively had the number of MII oocytes noted. Mean +SD using a 2-sided CI with p<0.05 ∗Only 18 and 19 patients for u-hCG and r-hCG, respectively had the number of MII oocytes noted. Conclusions: From these results, it is apparent that no difference exists between Ovidrel 250 mcg and 10,000 IU of u-hCG. Based on these results, our clinic believes Ovidrel is an effective and safe replacement for u-hCG 10,000 IU. 1Chang, FS 76: 1, pp 67–74, 2001. 2Driscoll, HR 15: 6, pp 1305–1310, 2000." @default.
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• W2081134662 date "2003-09-01" @default.
• W2081134662 modified "2023-09-30" @default.
• W2081134662 title "A retrospective analysis comparing outcomes data: Ovidrel 250mcg versus u-hCG in GnRH-agonist down regulated ART patients" @default.
• W2081134662 doi "https://doi.org/10.1016/s0015-0282(03)01251-2" @default.
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