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- W2081144792 abstract "Specific functional and pharmacological properties have recently been ascribed to G-protein-coupled receptor (GPCR) dimers/oligomers. Because the association of two identical or two distinct GPCR monomers seems to be required to elicit receptor function, it is necessary to understand the exact nature of this interaction. We present here a novel method for de novo protein design and its application to the prediction of mutations that can stabilize or destabilize a GPCR dimer while maintaining the monomer's native fold. To test the efficacy of this new method, the dimer of the single-spanned transmembrane domain of glycophorin A was used as a model system. Experimental data from mutagenesis of the helix-helix interface are compared with computational predictions at that interface, and the model's results are found to be consistent with the experimental findings. A flexible template was developed for the rhodopsin homodimer at atomic resolution and used to predict sets of three and five mutations. The results are found to be consistent across eight case studies, with favored mutations at each position. Mutation sets predicted to be the most disruptive at the dimerization interface are found to be less specific to the flexible template than sets predicted to be less disruptive." @default.
- W2081144792 created "2016-06-24" @default.
- W2081144792 creator A5000978218 @default.
- W2081144792 creator A5014370221 @default.
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- W2081144792 creator A5043092098 @default.
- W2081144792 creator A5049592533 @default.
- W2081144792 creator A5050187529 @default.
- W2081144792 date "2008-04-01" @default.
- W2081144792 modified "2023-09-29" @default.
- W2081144792 title "Mutations Affecting the Oligomerization Interface of G-Protein-Coupled Receptors Revealed by a Novel De Novo Protein Design Framework" @default.
- W2081144792 cites W1211108949 @default.
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- W2081144792 cites W1489377217 @default.
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- W2081144792 cites W1498712138 @default.
- W2081144792 cites W1509269256 @default.
- W2081144792 cites W1574312817 @default.
- W2081144792 cites W1581425946 @default.
- W2081144792 cites W1833104430 @default.
- W2081144792 cites W1966523142 @default.
- W2081144792 cites W1973987247 @default.
- W2081144792 cites W1975122118 @default.
- W2081144792 cites W1981009968 @default.
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- W2081144792 cites W1983562846 @default.
- W2081144792 cites W1984214206 @default.
- W2081144792 cites W1984425167 @default.
- W2081144792 cites W1984429646 @default.
- W2081144792 cites W199186236 @default.
- W2081144792 cites W1992181256 @default.
- W2081144792 cites W1992904904 @default.
- W2081144792 cites W1993697025 @default.
- W2081144792 cites W1995431912 @default.
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- W2081144792 cites W2020933513 @default.
- W2081144792 cites W2026279242 @default.
- W2081144792 cites W2027054953 @default.
- W2081144792 cites W2034271244 @default.
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- W2081144792 cites W2073110681 @default.
- W2081144792 cites W2074394454 @default.
- W2081144792 cites W2079052124 @default.
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- W2081144792 cites W2158606064 @default.
- W2081144792 cites W2165465265 @default.
- W2081144792 cites W2170907233 @default.
- W2081144792 cites W2411751083 @default.
- W2081144792 cites W2951597687 @default.
- W2081144792 cites W4251828057 @default.
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- W2081144792 doi "https://doi.org/10.1529/biophysj.107.117622" @default.
- W2081144792 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2267121" @default.
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- W2081144792 hasPublicationYear "2008" @default.
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