FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081146306> ?p ?o ?g. }

• W2081146306 endingPage "535" @default.
• W2081146306 startingPage "526" @default.
• W2081146306 abstract "Gender influence on left ventricular (LV) remodeling associated to aortic valve stenosis (AS) has been long recognized, but underlying myocardial gene expression patterns have not been explored. We studied whether sex differences in echocardiographic LV anatomy and function in AS patients are associated with specific changes in myocardial mRNA expression of remodeling proteins. AS (n=39) and control (n=23)patients were assessed echocardiographically, and LV myocardial mRNA levels were quantified by PCR. AS patients exhibit increased wall thicknesses and LV mass index (LVMI), but only men show chamber dilation.Collagens and fibronectin mRNA levels increased correlatively to transforming growth factor-beta1 (TGF-beta1). In AS women, collagen I upregulation was proportionally higher than other extracellular matrix (ECM)components. No changes in matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 were detected. Gene expressions of sarcomeric proteins (beta-myosin heavy chain and myosin light chain-2) and TGF-beta1 were directly correlated with each other. Myosin light chain-2 mRNA levels increased proportionally to the transvalvular gradient, but women did so in a greater extent than men for a given gradient. In women, the hypertrophic growth response, reflected by LVMI, was proportional to the expression of genes encoding sarcomeric proteins and TGF-beta1. In men, chamber dilation and deterioration of LVEF was proportional to collagens, fibronectin, and TGF-beta1 gene expression levels. We evidenced gender biased gene expression patterns of the intracellular TGF-beta pathways involving the Smad branch, but not the TAK-1 branch, that could contribute to the remodeling differences observed in AS men and women. Based on these findings, a gender specific therapeutic approach of pressure overload LV hypertrophy could be justified." @default.
• W2081146306 created "2016-06-24" @default.
• W2081146306 creator A5003823337 @default.
• W2081146306 creator A5005896903 @default.
• W2081146306 creator A5055921939 @default.
• W2081146306 creator A5059378979 @default.
• W2081146306 creator A5062793793 @default.
• W2081146306 creator A5076991806 @default.
• W2081146306 creator A5083888737 @default.
• W2081146306 creator A5089757170 @default.
• W2081146306 date "2009-04-01" @default.
• W2081146306 modified "2023-10-18" @default.
• W2081146306 title "Gender differences of echocardiographic and gene expression patterns in human pressure overload left ventricular hypertrophy" @default.
• W2081146306 cites W1532756122 @default.
• W2081146306 cites W1535326074 @default.
• W2081146306 cites W1572205294 @default.
• W2081146306 cites W1598829273 @default.
• W2081146306 cites W1602886522 @default.
• W2081146306 cites W1966498333 @default.
• W2081146306 cites W1979801633 @default.
• W2081146306 cites W1982469770 @default.
• W2081146306 cites W1983692570 @default.
• W2081146306 cites W1986882289 @default.
• W2081146306 cites W1995934832 @default.
• W2081146306 cites W1997176820 @default.
• W2081146306 cites W2000857746 @default.
• W2081146306 cites W2004656949 @default.
• W2081146306 cites W2005874915 @default.
• W2081146306 cites W2006281459 @default.
• W2081146306 cites W2006660609 @default.
• W2081146306 cites W2014242603 @default.
• W2081146306 cites W2018353023 @default.
• W2081146306 cites W2027082110 @default.
• W2081146306 cites W2035653659 @default.
• W2081146306 cites W2037030280 @default.
• W2081146306 cites W2037749195 @default.
• W2081146306 cites W2046275861 @default.
• W2081146306 cites W2051155595 @default.
• W2081146306 cites W2080150476 @default.
• W2081146306 cites W2081848148 @default.
• W2081146306 cites W2094914396 @default.
• W2081146306 cites W2095605427 @default.
• W2081146306 cites W2104390222 @default.
• W2081146306 cites W2105161080 @default.
• W2081146306 cites W2116091611 @default.
• W2081146306 cites W2137542902 @default.
• W2081146306 cites W2141761365 @default.
• W2081146306 cites W2148075660 @default.
• W2081146306 cites W2151442377 @default.
• W2081146306 cites W2154568166 @default.
• W2081146306 cites W2161864778 @default.
• W2081146306 cites W2161918376 @default.
• W2081146306 cites W2162514162 @default.
• W2081146306 cites W2168050306 @default.
• W2081146306 cites W2168915540 @default.
• W2081146306 cites W2169083489 @default.
• W2081146306 cites W2170459650 @default.
• W2081146306 cites W2171243928 @default.
• W2081146306 cites W2274090621 @default.
• W2081146306 cites W4232767515 @default.
• W2081146306 cites W4249341602 @default.
• W2081146306 doi "https://doi.org/10.1016/j.yjmcc.2008.12.024" @default.
• W2081146306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19639678" @default.
• W2081146306 hasPublicationYear "2009" @default.
• W2081146306 type Work @default.
• W2081146306 sameAs 2081146306 @default.
• W2081146306 citedByCount "68" @default.
• W2081146306 countsByYear W20811463062012 @default.
• W2081146306 countsByYear W20811463062013 @default.
• W2081146306 countsByYear W20811463062014 @default.
• W2081146306 countsByYear W20811463062015 @default.
• W2081146306 countsByYear W20811463062016 @default.
• W2081146306 countsByYear W20811463062017 @default.
• W2081146306 countsByYear W20811463062018 @default.
• W2081146306 countsByYear W20811463062019 @default.
• W2081146306 countsByYear W20811463062020 @default.
• W2081146306 countsByYear W20811463062021 @default.
• W2081146306 countsByYear W20811463062022 @default.
• W2081146306 crossrefType "journal-article" @default.
• W2081146306 hasAuthorship W2081146306A5003823337 @default.
• W2081146306 hasAuthorship W2081146306A5005896903 @default.
• W2081146306 hasAuthorship W2081146306A5055921939 @default.
• W2081146306 hasAuthorship W2081146306A5059378979 @default.
• W2081146306 hasAuthorship W2081146306A5062793793 @default.
• W2081146306 hasAuthorship W2081146306A5076991806 @default.
• W2081146306 hasAuthorship W2081146306A5083888737 @default.
• W2081146306 hasAuthorship W2081146306A5089757170 @default.
• W2081146306 hasConcept C104317684 @default.
• W2081146306 hasConcept C118131993 @default.
• W2081146306 hasConcept C126322002 @default.
• W2081146306 hasConcept C134018914 @default.
• W2081146306 hasConcept C150194340 @default.
• W2081146306 hasConcept C164705383 @default.
• W2081146306 hasConcept C167414201 @default.
• W2081146306 hasConcept C189165786 @default.
• W2081146306 hasConcept C2778122751 @default.
• W2081146306 hasConcept C2778271984 @default.
• W2081146306 hasConcept C2779537366 @default.

• next