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• W2081147478 abstract "1. SK&F 101468, a non phenolic indolone derivative, has been characterised preclinically as a novel, potent and specific dopamine D2-receptor agonist. 2. Its tolerability and effects on serum prolactin were investigated in 14 healthy male volunteers in a study of the first administration of SK&F 101468 to man. 3. Doses between 80 micrograms and 2.5 mg caused statistically significant (P less than 0.05) lowering of basal and food stimulated serum prolactin, relative to placebo, over a 6 h post treatment period. 4. SK&F 101468 was well tolerated up to 1 mg with symptoms of nausea and postural hypotension at higher doses." @default.
• W2081147478 created "2016-06-24" @default.
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• W2081147478 date "1989-10-01" @default.
• W2081147478 modified "2023-10-06" @default.
• W2081147478 title "A dose rising study of the safety and effects on serum prolactin of SK&F 101468, a novel dopamine D2-receptor agonist." @default.
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• W2081147478 doi "https://doi.org/10.1111/j.1365-2125.1989.tb03524.x" @default.
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