Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081151783> ?p ?o ?g. }
- W2081151783 endingPage "462" @default.
- W2081151783 startingPage "452" @default.
- W2081151783 abstract "The structure of the complement-binding domain of Staphylococcus aureus protein Sbi (Sbi-IV) in complex with ligand C3d is presented. The 1.7Å resolution structure reveals the molecular details of the recognition of thioester-containing fragment C3d of the central complement component C3, involving interactions between residues of Sbi-IV helix α2 and the acidic concave surface of C3d. The complex provides a structural basis for the binding preference of Sbi for native C3 over C3b and explains how Sbi-IV inhibits the interaction between C3d and complement receptor 2. A second C3d binding site on Sbi-IV is identified in the crystal structure that is not observed in related S. aureus C3 inhibitors Efb-C and Ehp. This binding mode perhaps hints as to how Sbi-IV, as part of Sbi, forms a C3b-Sbi adduct and causes futile consumption of C3, an extraordinary aspect of Sbi function that is not shared by any other known Staphylococcal complement inhibitor." @default.
- W2081151783 created "2016-06-24" @default.
- W2081151783 creator A5011986079 @default.
- W2081151783 creator A5013194047 @default.
- W2081151783 creator A5021717737 @default.
- W2081151783 creator A5026032024 @default.
- W2081151783 creator A5029894369 @default.
- W2081151783 creator A5036949719 @default.
- W2081151783 creator A5057753149 @default.
- W2081151783 creator A5081712139 @default.
- W2081151783 date "2011-01-01" @default.
- W2081151783 modified "2023-09-27" @default.
- W2081151783 title "A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d" @default.
- W2081151783 cites W1520730837 @default.
- W2081151783 cites W1539796472 @default.
- W2081151783 cites W1570116363 @default.
- W2081151783 cites W1977038370 @default.
- W2081151783 cites W1977179663 @default.
- W2081151783 cites W1982126789 @default.
- W2081151783 cites W1998930337 @default.
- W2081151783 cites W2000212874 @default.
- W2081151783 cites W2001641653 @default.
- W2081151783 cites W2011385850 @default.
- W2081151783 cites W2021375991 @default.
- W2081151783 cites W2035503835 @default.
- W2081151783 cites W2037341401 @default.
- W2081151783 cites W2050091361 @default.
- W2081151783 cites W2054891189 @default.
- W2081151783 cites W2058527555 @default.
- W2081151783 cites W2070879495 @default.
- W2081151783 cites W2072674961 @default.
- W2081151783 cites W2078245915 @default.
- W2081151783 cites W2080283280 @default.
- W2081151783 cites W2091933198 @default.
- W2081151783 cites W2099361127 @default.
- W2081151783 cites W2104555813 @default.
- W2081151783 cites W2113031999 @default.
- W2081151783 cites W2118818078 @default.
- W2081151783 cites W2119211468 @default.
- W2081151783 cites W2119768770 @default.
- W2081151783 cites W2119879750 @default.
- W2081151783 cites W2124983865 @default.
- W2081151783 cites W2141596893 @default.
- W2081151783 cites W2142421435 @default.
- W2081151783 cites W2143166347 @default.
- W2081151783 cites W2144081223 @default.
- W2081151783 cites W2144278357 @default.
- W2081151783 cites W2151669381 @default.
- W2081151783 cites W2156625232 @default.
- W2081151783 cites W2162593826 @default.
- W2081151783 cites W2169707043 @default.
- W2081151783 cites W2169821755 @default.
- W2081151783 cites W2314649741 @default.
- W2081151783 doi "https://doi.org/10.1016/j.molimm.2010.09.017" @default.
- W2081151783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3025320" @default.
- W2081151783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21055811" @default.
- W2081151783 hasPublicationYear "2011" @default.
- W2081151783 type Work @default.
- W2081151783 sameAs 2081151783 @default.
- W2081151783 citedByCount "23" @default.
- W2081151783 countsByYear W20811517832012 @default.
- W2081151783 countsByYear W20811517832014 @default.
- W2081151783 countsByYear W20811517832015 @default.
- W2081151783 countsByYear W20811517832016 @default.
- W2081151783 countsByYear W20811517832018 @default.
- W2081151783 countsByYear W20811517832019 @default.
- W2081151783 countsByYear W20811517832020 @default.
- W2081151783 countsByYear W20811517832021 @default.
- W2081151783 countsByYear W20811517832022 @default.
- W2081151783 countsByYear W20811517832023 @default.
- W2081151783 crossrefType "journal-article" @default.
- W2081151783 hasAuthorship W2081151783A5011986079 @default.
- W2081151783 hasAuthorship W2081151783A5013194047 @default.
- W2081151783 hasAuthorship W2081151783A5021717737 @default.
- W2081151783 hasAuthorship W2081151783A5026032024 @default.
- W2081151783 hasAuthorship W2081151783A5029894369 @default.
- W2081151783 hasAuthorship W2081151783A5036949719 @default.
- W2081151783 hasAuthorship W2081151783A5057753149 @default.
- W2081151783 hasAuthorship W2081151783A5081712139 @default.
- W2081151783 hasBestOaLocation W20811517831 @default.
- W2081151783 hasConcept C104317684 @default.
- W2081151783 hasConcept C107824862 @default.
- W2081151783 hasConcept C111684460 @default.
- W2081151783 hasConcept C112313634 @default.
- W2081151783 hasConcept C115624301 @default.
- W2081151783 hasConcept C116569031 @default.
- W2081151783 hasConcept C127716648 @default.
- W2081151783 hasConcept C159654299 @default.
- W2081151783 hasConcept C170493617 @default.
- W2081151783 hasConcept C185592680 @default.
- W2081151783 hasConcept C188082640 @default.
- W2081151783 hasConcept C203014093 @default.
- W2081151783 hasConcept C25166345 @default.
- W2081151783 hasConcept C2779489039 @default.
- W2081151783 hasConcept C51639874 @default.
- W2081151783 hasConcept C523546767 @default.
- W2081151783 hasConcept C54355233 @default.
- W2081151783 hasConcept C55493867 @default.