FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081154679> ?p ?o ?g. }

• W2081154679 endingPage "454" @default.
• W2081154679 startingPage "454" @default.
• W2081154679 abstract "The anaerobic spirochaete Brachyspira pilosicoli causes enteric disease in avian, porcine and human hosts, amongst others. To date, the only available genome sequence of B. pilosicoli is that of strain 95/1000, a porcine isolate. In the first intra-species genome comparison within the Brachyspira genus, we report the whole genome sequence of B. pilosicoli B2904, an avian isolate, the incomplete genome sequence of B. pilosicoli WesB, a human isolate, and the comparisons with B. pilosicoli 95/1000. We also draw on incomplete genome sequences from three other Brachyspira species. Finally we report the first application of the high-throughput Biolog phenotype screening tool on the B. pilosicoli strains for detailed comparisons between genotype and phenotype. Feature and sequence genome comparisons revealed a high degree of similarity between the three B. pilosicoli strains, although the genomes of B2904 and WesB were larger than that of 95/1000 (~2,765, 2.890 and 2.596 Mb, respectively). Genome rearrangements were observed which correlated largely with the positions of mobile genetic elements. Through comparison of the B2904 and WesB genomes with the 95/1000 genome, features that we propose are non-essential due to their absence from 95/1000 include a peptidase, glycine reductase complex components and transposases. Novel bacteriophages were detected in the newly-sequenced genomes, which appeared to have involvement in intra- and inter-species horizontal gene transfer. Phenotypic differences predicted from genome analysis, such as the lack of genes for glucuronate catabolism in 95/1000, were confirmed by phenotyping. The availability of multiple B. pilosicoli genome sequences has allowed us to demonstrate the substantial genomic variation that exists between these strains, and provides an insight into genetic events that are shaping the species. In addition, phenotype screening allowed determination of how genotypic differences translated to phenotype. Further application of such comparisons will improve understanding of the metabolic capabilities of Brachyspira species." @default.
• W2081154679 created "2016-06-24" @default.
• W2081154679 creator A5004050862 @default.
• W2081154679 creator A5019062325 @default.
• W2081154679 creator A5021655313 @default.
• W2081154679 creator A5044207304 @default.
• W2081154679 creator A5049389523 @default.
• W2081154679 creator A5049826232 @default.
• W2081154679 creator A5053469584 @default.
• W2081154679 creator A5065858202 @default.
• W2081154679 creator A5077121860 @default.
• W2081154679 creator A5084268602 @default.
• W2081154679 creator A5086798469 @default.
• W2081154679 creator A5090793145 @default.
• W2081154679 date "2012-01-01" @default.
• W2081154679 modified "2023-10-12" @default.
• W2081154679 title "Comparative genomics of Brachyspira pilosicoli strains: genome rearrangements, reductions and correlation of genetic compliment with phenotypic diversity" @default.
• W2081154679 cites W1965404910 @default.
• W2081154679 cites W1966614672 @default.
• W2081154679 cites W1974524365 @default.
• W2081154679 cites W1977293483 @default.
• W2081154679 cites W1984852783 @default.
• W2081154679 cites W1987494296 @default.
• W2081154679 cites W1989125999 @default.
• W2081154679 cites W1991486683 @default.
• W2081154679 cites W1995805750 @default.
• W2081154679 cites W2002318349 @default.
• W2081154679 cites W2003557868 @default.
• W2081154679 cites W2015921211 @default.
• W2081154679 cites W2019571990 @default.
• W2081154679 cites W2024535015 @default.
• W2081154679 cites W2029291491 @default.
• W2081154679 cites W2031982444 @default.
• W2081154679 cites W2032054300 @default.
• W2081154679 cites W2032162135 @default.
• W2081154679 cites W2037747413 @default.
• W2081154679 cites W2040742249 @default.
• W2081154679 cites W2040861032 @default.
• W2081154679 cites W2042389184 @default.
• W2081154679 cites W2046215004 @default.
• W2081154679 cites W2051702142 @default.
• W2081154679 cites W2054521685 @default.
• W2081154679 cites W2054896894 @default.
• W2081154679 cites W2062507766 @default.
• W2081154679 cites W2063143267 @default.
• W2081154679 cites W2066915800 @default.
• W2081154679 cites W2071037031 @default.
• W2081154679 cites W2082642898 @default.
• W2081154679 cites W2085543266 @default.
• W2081154679 cites W2086010696 @default.
• W2081154679 cites W2097948463 @default.
• W2081154679 cites W2098441416 @default.
• W2081154679 cites W2099333915 @default.
• W2081154679 cites W2102131597 @default.
• W2081154679 cites W2104720659 @default.
• W2081154679 cites W2104809921 @default.
• W2081154679 cites W2107179169 @default.
• W2081154679 cites W2107738771 @default.
• W2081154679 cites W2110470553 @default.
• W2081154679 cites W2111448683 @default.
• W2081154679 cites W2113780464 @default.
• W2081154679 cites W2116513121 @default.
• W2081154679 cites W2116902249 @default.
• W2081154679 cites W2118443091 @default.
• W2081154679 cites W2127983091 @default.
• W2081154679 cites W2132632499 @default.
• W2081154679 cites W2133691154 @default.
• W2081154679 cites W2137015675 @default.
• W2081154679 cites W2137058189 @default.
• W2081154679 cites W2139760555 @default.
• W2081154679 cites W2141306398 @default.
• W2081154679 cites W2142153279 @default.
• W2081154679 cites W2143737249 @default.
• W2081154679 cites W2146181562 @default.
• W2081154679 cites W2146389940 @default.
• W2081154679 cites W2147430800 @default.
• W2081154679 cites W2149578294 @default.
• W2081154679 cites W2154203929 @default.
• W2081154679 cites W2155534524 @default.
• W2081154679 cites W2156664574 @default.
• W2081154679 cites W2157399903 @default.
• W2081154679 cites W2162198166 @default.
• W2081154679 cites W2168447303 @default.
• W2081154679 cites W2169325493 @default.
• W2081154679 cites W2171467729 @default.
• W2081154679 cites W2320028071 @default.
• W2081154679 cites W4213236156 @default.
• W2081154679 cites W4249132097 @default.
• W2081154679 doi "https://doi.org/10.1186/1471-2164-13-454" @default.
• W2081154679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3532143" @default.
• W2081154679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22947175" @default.
• W2081154679 hasPublicationYear "2012" @default.
• W2081154679 type Work @default.
• W2081154679 sameAs 2081154679 @default.
• W2081154679 citedByCount "41" @default.
• W2081154679 countsByYear W20811546792013 @default.
• W2081154679 countsByYear W20811546792014 @default.
• W2081154679 countsByYear W20811546792015 @default.

• next