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- W2081161013 abstract "The content of DNA polymerase β in whole rat testes drastically decreased upon hypophysectomy: at 1 and 2 weeks, to 12.5% and 5% of the control testes of sham-operated rats, respectively. DNA polymerase β activity per cell (per milligram DNA) also decreased to 14% of the control within 2 weeks after hypophysectomy. The DNA polymerase α in the testis also decreased, but the DNA polymerase γ was relatively resistant to hypophysectomy. The testicular DNA polymerase β from hypophysectomized rats sedimented at 4.5 S, whereas that from sham-operated controls sedimented at 3.3 S. The reduced level of testicular DNA polymerase β and the change in molecular size induced by hypophysectomy were largely reversed by daily injections of LH and FSH. The reduced activity was also fully reversed by the injection of testosterone. These results suggest that the level of DNA polymerase β in the rat testis depends largely on the level of testosterone produced by Leydig cells in the testis itself, but is also regulated by pituitary gonadotropins. (Endocrinology115: 1110–1115, 1984)" @default.
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- W2081161013 date "1984-09-01" @default.
- W2081161013 modified "2023-10-18" @default.
- W2081161013 title "Hormonal Regulation of Deoxyribonucleic Acid Polymerase<i>β</i>Activity in Rat Testis*" @default.
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- W2081161013 doi "https://doi.org/10.1210/endo-115-3-1110" @default.
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