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• W2081164457 abstract "During fetal development of the anterior pituitary gland, a number of sequential processes occur that affect cell differentiation and proliferation. Molecular analyses have revealed several steps that are required for pituitary cell line specification and have identified specific factors that control these steps. The gene encoding the pituitary transcription factor 1 (Pit-1) is expressed during differentiation steps that take place quite late in the development of the anterior pituitary gland. Clinically, patients with mutations of the PIT1 gene are characterized by severe deficiencies in growth hormone (GH) and prolactin (PRL), and often develop secondary hypothyroidism. A second pituitary transcription factor is known as Prophet of Pit-1 (Prop-1), and a mutation of the Prop1 gene has been detected in Ames dwarf mice. Several Prop1 mutations have been identified that structurally affect the 'paired-like' DNA-binding domain of the Prop-1 protein molecule. Patients with PROP1 mutations show combined pituitary hormone deficiency. These patients exhibit secondary hypogonadism in addition to the deficiencies of GH, PRL and thyroid-stimulating hormone (TSH) also seen in patients with PIT1 mutations. Although all are in the subnormal range, the levels of GH, PRL and TSH in patients with PROP1 mutations are, on average, slightly higher than in patients with PIT1 mutations. Some degree of hypocortisolism may necessitate cortisol substitution in patients with PROP1 mutations." @default.
• W2081164457 created "2016-06-24" @default.
• W2081164457 creator A5054252029 @default.
• W2081164457 creator A5055762191 @default.
• W2081164457 creator A5086940512 @default.
• W2081164457 creator A5087165141 @default.
• W2081164457 date "1999-12-01" @default.
• W2081164457 modified "2023-10-17" @default.
• W2081164457 title "Combined pituirary hormone deficency: role of Pit-1 and Prop-1" @default.
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• W2081164457 doi "https://doi.org/10.1111/j.1651-2227.1999.tb14401.x" @default.
• W2081164457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10626543" @default.
• W2081164457 hasPublicationYear "1999" @default.
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