FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081170087> ?p ?o ?g. }

• W2081170087 endingPage "8" @default.
• W2081170087 startingPage "1" @default.
• W2081170087 abstract "The actin binding protein CapG modulates cell motility by interacting with the cytoskeleton. CapG is associated with tumor progression in different nongynecologic tumor entities and overexpression in breast cancer cell lines correlates with a more invasive phenotype in vitro. Here, we report a significant CapG overexpression in 18/47 (38%) of ovarian carcinomas (OC) analyzed by qRealTime-PCR analyses. Functional analyses in OC cell lines through siRNA mediated CapG knockdown and CapG overexpression showed CapG-dependent cell migration and invasiveness. A single nucleotide polymorphism rs6886 inside the CapG gene was identified, affecting a CapG phosphorylation site and thus potentially modifying CapG function. The minor allele frequency (MAF) of SNP rs6886 (c.1004A/G) was higher and the homozygous (A/A, His335) genotype was significantly more prevalent in patients with fallopian tube carcinomas (50%) as in controls (10%). With OC being one of the most lethal cancer diseases, the detection of novel biomarkers such as CapG could reveal new diagnostic and therapeutic targets. Moreover, in-depth analyses of SNP rs6886 related to FTC and OC will contribute to a better understanding of carcinogenesis and progression of OC." @default.
• W2081170087 created "2016-06-24" @default.
• W2081170087 creator A5007843360 @default.
• W2081170087 creator A5011069826 @default.
• W2081170087 creator A5022051693 @default.
• W2081170087 creator A5023857818 @default.
• W2081170087 creator A5033918537 @default.
• W2081170087 creator A5061791206 @default.
• W2081170087 creator A5069879012 @default.
• W2081170087 creator A5074946730 @default.
• W2081170087 creator A5077674559 @default.
• W2081170087 creator A5086791040 @default.
• W2081170087 date "2014-01-01" @default.
• W2081170087 modified "2023-10-17" @default.
• W2081170087 title "Macrophage Capping Protein CapG Is a Putative Oncogene Involved in Migration and Invasiveness in Ovarian Carcinoma" @default.
• W2081170087 cites W1560663807 @default.
• W2081170087 cites W1600808722 @default.
• W2081170087 cites W1961928411 @default.
• W2081170087 cites W1989685930 @default.
• W2081170087 cites W2017408894 @default.
• W2081170087 cites W2026695260 @default.
• W2081170087 cites W2042633087 @default.
• W2081170087 cites W2051520825 @default.
• W2081170087 cites W2063663674 @default.
• W2081170087 cites W2070369494 @default.
• W2081170087 cites W2081500553 @default.
• W2081170087 cites W2084376590 @default.
• W2081170087 cites W2088769048 @default.
• W2081170087 cites W2089665951 @default.
• W2081170087 cites W2092999618 @default.
• W2081170087 cites W2094148152 @default.
• W2081170087 cites W2096136044 @default.
• W2081170087 cites W2098166298 @default.
• W2081170087 cites W2100248081 @default.
• W2081170087 cites W2100837269 @default.
• W2081170087 cites W2118667301 @default.
• W2081170087 cites W2130873698 @default.
• W2081170087 cites W2136308102 @default.
• W2081170087 cites W2142997114 @default.
• W2081170087 cites W2143025387 @default.
• W2081170087 cites W2143468862 @default.
• W2081170087 cites W2144169031 @default.
• W2081170087 cites W2147141733 @default.
• W2081170087 cites W2156562219 @default.
• W2081170087 cites W2160944682 @default.
• W2081170087 cites W2168358204 @default.
• W2081170087 doi "https://doi.org/10.1155/2014/379847" @default.
• W2081170087 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3996954" @default.
• W2081170087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24804218" @default.
• W2081170087 hasPublicationYear "2014" @default.
• W2081170087 type Work @default.
• W2081170087 sameAs 2081170087 @default.
• W2081170087 citedByCount "29" @default.
• W2081170087 countsByYear W20811700872015 @default.
• W2081170087 countsByYear W20811700872016 @default.
• W2081170087 countsByYear W20811700872017 @default.
• W2081170087 countsByYear W20811700872018 @default.
• W2081170087 countsByYear W20811700872019 @default.
• W2081170087 countsByYear W20811700872020 @default.
• W2081170087 countsByYear W20811700872021 @default.
• W2081170087 countsByYear W20811700872022 @default.
• W2081170087 countsByYear W20811700872023 @default.
• W2081170087 crossrefType "journal-article" @default.
• W2081170087 hasAuthorship W2081170087A5007843360 @default.
• W2081170087 hasAuthorship W2081170087A5011069826 @default.
• W2081170087 hasAuthorship W2081170087A5022051693 @default.
• W2081170087 hasAuthorship W2081170087A5023857818 @default.
• W2081170087 hasAuthorship W2081170087A5033918537 @default.
• W2081170087 hasAuthorship W2081170087A5061791206 @default.
• W2081170087 hasAuthorship W2081170087A5069879012 @default.
• W2081170087 hasAuthorship W2081170087A5074946730 @default.
• W2081170087 hasAuthorship W2081170087A5077674559 @default.
• W2081170087 hasAuthorship W2081170087A5086791040 @default.
• W2081170087 hasBestOaLocation W20811700871 @default.
• W2081170087 hasConcept C104317684 @default.
• W2081170087 hasConcept C121608353 @default.
• W2081170087 hasConcept C135763542 @default.
• W2081170087 hasConcept C1491633281 @default.
• W2081170087 hasConcept C2779013556 @default.
• W2081170087 hasConcept C2780427987 @default.
• W2081170087 hasConcept C2781018059 @default.
• W2081170087 hasConcept C29537977 @default.
• W2081170087 hasConcept C502942594 @default.
• W2081170087 hasConcept C54355233 @default.
• W2081170087 hasConcept C555283112 @default.
• W2081170087 hasConcept C81885089 @default.
• W2081170087 hasConcept C86803240 @default.
• W2081170087 hasConceptScore W2081170087C104317684 @default.
• W2081170087 hasConceptScore W2081170087C121608353 @default.
• W2081170087 hasConceptScore W2081170087C135763542 @default.
• W2081170087 hasConceptScore W2081170087C1491633281 @default.
• W2081170087 hasConceptScore W2081170087C2779013556 @default.
• W2081170087 hasConceptScore W2081170087C2780427987 @default.
• W2081170087 hasConceptScore W2081170087C2781018059 @default.
• W2081170087 hasConceptScore W2081170087C29537977 @default.
• W2081170087 hasConceptScore W2081170087C502942594 @default.
• W2081170087 hasConceptScore W2081170087C54355233 @default.
• W2081170087 hasConceptScore W2081170087C555283112 @default.

• next