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- W2081172134 abstract "Biomaterials designed to mimic the intricate native extracellular matrix (ECM) can use a variety of techniques to control the behavior of encapsulated cells. Common methods include controlling the mechanical properties of the material, incorporating bioactive signals, spatially patterning bioactive signals, and controlling the time-release of bioactive signals. Further design parameters like bioactive signal distribution can be used to manipulate cell behavior. Efforts on clustering adhesion peptides have focused on seeding cells on top of a biomaterial. Here we report the effect of clustering the adhesion peptide RGD on mouse mesenchymal stem cells encapsulated inside three-dimensional hyaluronic acid hydrogels. The clustered bioactive signals resulted in significant differences in both cell spreading and integrin expression. These results indicate that signal RGD peptide clustering is an additional hydrogel design parameter can be used to influence and guide the behavior of encapsulated cells." @default.
- W2081172134 created "2016-06-24" @default.
- W2081172134 creator A5023263888 @default.
- W2081172134 creator A5047143411 @default.
- W2081172134 date "2013-05-01" @default.
- W2081172134 modified "2023-10-07" @default.
- W2081172134 title "The modulation of MSC integrin expression by RGD presentation" @default.
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- W2081172134 doi "https://doi.org/10.1016/j.biomaterials.2013.01.091" @default.
- W2081172134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3650837" @default.
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