Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081175739> ?p ?o ?g. }
- W2081175739 endingPage "316" @default.
- W2081175739 startingPage "307" @default.
- W2081175739 abstract "The effects of topical application of neutral formaldehyde (1%) and intracameral administration of calcitonin gene-related peptide (CGRP, 0·5- or 2·0μg) on the intraocular pressure (IOP), blood-aqueous barrier, pupil size, blood pressure and cyclic AMP (cAMP) content in the aqueous humour of a rabbit were studied. Topical chemical irritation with 1% formaldehyde caused a typical irritative response in the eye with a rise in the IOP, breakdown of the blood-aqueous barrier and miosis. The cAMP content in the aqueous humour was also increased (88·5 ± 35·0 pmol ml−1, P < 0·05) when compared with the control group (16·3 ± 3·6 pmol ml−1). Intracameral administration of CGRP caused a rise in the IOP, breakdown of the blood-aqueous barrier and also systemic hypotension. Miosis was not observed after intracameral CGRP but an increase in the cAMP content in the aqueous humour was seen (130·5 ± 30·3- and 158·7 ± 48·1 pmol ml−1, both P < 0·01, after 0·5 or 2·0 μg, respectively). The cAMP concentration in the aqueous humour after topical chemical irritation and intracameral CGRP correlated with the intensity of the breakdown of the blood-aqueous barrier. CGRP seems to cause most, but not all, of the ocular changes after sensory nerve stimulation elicited by topical neutral formaldehyde. Of these CGRP-induced changes, only the breakdown of the blood-aqueous barrier is related to an increase in the cAMP content in the aqueous humour. Contralateral responses after sensory nerve stimulation were similar to contralateral responses to intracameral CGRP." @default.
- W2081175739 created "2016-06-24" @default.
- W2081175739 creator A5019317897 @default.
- W2081175739 date "1988-08-01" @default.
- W2081175739 modified "2023-09-27" @default.
- W2081175739 title "CGRP in relation to neurogenic inflammation and cAMP in the rabbit eye" @default.
- W2081175739 cites W1506673182 @default.
- W2081175739 cites W173746587 @default.
- W2081175739 cites W1775749144 @default.
- W2081175739 cites W1964421495 @default.
- W2081175739 cites W1968627867 @default.
- W2081175739 cites W1969699551 @default.
- W2081175739 cites W1970509343 @default.
- W2081175739 cites W1974775584 @default.
- W2081175739 cites W1988325008 @default.
- W2081175739 cites W1997044455 @default.
- W2081175739 cites W1999147380 @default.
- W2081175739 cites W2001385401 @default.
- W2081175739 cites W2006827583 @default.
- W2081175739 cites W2017753138 @default.
- W2081175739 cites W2020335694 @default.
- W2081175739 cites W2024149333 @default.
- W2081175739 cites W2029611528 @default.
- W2081175739 cites W2035491450 @default.
- W2081175739 cites W2035581625 @default.
- W2081175739 cites W2038753552 @default.
- W2081175739 cites W2046731801 @default.
- W2081175739 cites W2050635513 @default.
- W2081175739 cites W2052385273 @default.
- W2081175739 cites W2053277833 @default.
- W2081175739 cites W2061983691 @default.
- W2081175739 cites W2065948307 @default.
- W2081175739 cites W2069252221 @default.
- W2081175739 cites W2070762250 @default.
- W2081175739 cites W2077652001 @default.
- W2081175739 cites W2081762911 @default.
- W2081175739 cites W2085499088 @default.
- W2081175739 cites W2086727023 @default.
- W2081175739 cites W2152848856 @default.
- W2081175739 cites W2414686393 @default.
- W2081175739 cites W4230924007 @default.
- W2081175739 cites W2076931766 @default.
- W2081175739 doi "https://doi.org/10.1016/0014-4835(88)90013-9" @default.
- W2081175739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2842178" @default.
- W2081175739 hasPublicationYear "1988" @default.
- W2081175739 type Work @default.
- W2081175739 sameAs 2081175739 @default.
- W2081175739 citedByCount "23" @default.
- W2081175739 countsByYear W20811757392015 @default.
- W2081175739 countsByYear W20811757392018 @default.
- W2081175739 countsByYear W20811757392020 @default.
- W2081175739 crossrefType "journal-article" @default.
- W2081175739 hasAuthorship W2081175739A5019317897 @default.
- W2081175739 hasConcept C118303440 @default.
- W2081175739 hasConcept C118487528 @default.
- W2081175739 hasConcept C134018914 @default.
- W2081175739 hasConcept C163170386 @default.
- W2081175739 hasConcept C170493617 @default.
- W2081175739 hasConcept C185592680 @default.
- W2081175739 hasConcept C203014093 @default.
- W2081175739 hasConcept C24998067 @default.
- W2081175739 hasConcept C2777063393 @default.
- W2081175739 hasConcept C2777724181 @default.
- W2081175739 hasConcept C2779984381 @default.
- W2081175739 hasConcept C2781092963 @default.
- W2081175739 hasConcept C42219234 @default.
- W2081175739 hasConcept C55493867 @default.
- W2081175739 hasConcept C71924100 @default.
- W2081175739 hasConceptScore W2081175739C118303440 @default.
- W2081175739 hasConceptScore W2081175739C118487528 @default.
- W2081175739 hasConceptScore W2081175739C134018914 @default.
- W2081175739 hasConceptScore W2081175739C163170386 @default.
- W2081175739 hasConceptScore W2081175739C170493617 @default.
- W2081175739 hasConceptScore W2081175739C185592680 @default.
- W2081175739 hasConceptScore W2081175739C203014093 @default.
- W2081175739 hasConceptScore W2081175739C24998067 @default.
- W2081175739 hasConceptScore W2081175739C2777063393 @default.
- W2081175739 hasConceptScore W2081175739C2777724181 @default.
- W2081175739 hasConceptScore W2081175739C2779984381 @default.
- W2081175739 hasConceptScore W2081175739C2781092963 @default.
- W2081175739 hasConceptScore W2081175739C42219234 @default.
- W2081175739 hasConceptScore W2081175739C55493867 @default.
- W2081175739 hasConceptScore W2081175739C71924100 @default.
- W2081175739 hasIssue "2" @default.
- W2081175739 hasLocation W20811757391 @default.
- W2081175739 hasLocation W20811757392 @default.
- W2081175739 hasOpenAccess W2081175739 @default.
- W2081175739 hasPrimaryLocation W20811757391 @default.
- W2081175739 hasRelatedWork W1978802585 @default.
- W2081175739 hasRelatedWork W2010632604 @default.
- W2081175739 hasRelatedWork W2017753138 @default.
- W2081175739 hasRelatedWork W2021018357 @default.
- W2081175739 hasRelatedWork W2038763126 @default.
- W2081175739 hasRelatedWork W2081175739 @default.
- W2081175739 hasRelatedWork W2087566025 @default.
- W2081175739 hasRelatedWork W2417475121 @default.
- W2081175739 hasRelatedWork W2748952813 @default.
- W2081175739 hasRelatedWork W2899084033 @default.