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- W2081187017 abstract "We describe here an alternative procedure for assessing hindlimb locomotor function after spinal cord injury that uses the BBB scale, but tests animals in a reward-baited straight alley rather than an open field. Rats were trained to ambulate in a straight alley and habituated to the open field typically used for BBB open field testing. Three groups of rats were tested. Sprague-Dawley rats received either 200 kD (n=19) or 300 kD contusions (n=9) at T9 with the Infinite Horizon device. Fisher rats (n=8) received moderate contusions (12.5 mm) at T8 with the NYU impactor. BBB scores were assessed at different post-injury intervals in the open field and the straight alley, and scores were compared by correlation analyses. BBB scores in the open field vs. the straight alley were highly correlated (r=0.90), validating the use of the straight alley for locomotor assessment. Rats exhibited a larger number of bouts of continuous steps in the straight alley vs. the open field (termed passes), providing more opportunities to score hindlimb use and coordination over the 4 min testing interval. Comparisons of scores across days revealed higher day-to-day correlations in the straight alley vs. the open field (r(2) values of 0.90 and 0.74 for the straight alley and open field respectively), revealing that the straight alley yielded more reliable scores." @default.
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- W2081187017 date "2009-06-01" @default.
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- W2081187017 title "A straight alley version of the BBB locomotor scale" @default.
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- W2081187017 doi "https://doi.org/10.1016/j.expneurol.2009.03.037" @default.
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