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- W2081193330 abstract "Methionine dependence is the inability of cells to grow when methionine (Met) is replaced by its immediate precursor homocysteine (Hcy) in the culture medium (Met−Hcy+ medium). All normal unestablished cell strains tested to date have been shown to be methionine-independent and thus grow almost as well in Met−Hcy+ medium as they do in Met+Hcy− medium. Results presented here indicate that out of 23 cell lines derived from diverse types of human tumors, 11 do not grow at all in Met−Hcy+ medium and are absolutely methionine-dependent and 3 grow only slightly in this medium. Many of the tumor cell lines tested have little else in common other than the fact that they are methionine-dependent. The high frequency of occurrence of methionine dependence in diverse types of human tumor cells indicates that methionine dependence may be an important aspect of oncogenic transformation and therapeutically exploitable." @default.
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- W2081193330 date "1983-12-01" @default.
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- W2081193330 title "The metabolic defect of methionine dependence occurs frequently in human tumor cell lines" @default.
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- W2081193330 doi "https://doi.org/10.1016/0006-291x(83)91218-4" @default.
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