FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081232907> ?p ?o ?g. }

• W2081232907 endingPage "173" @default.
• W2081232907 startingPage "164" @default.
• W2081232907 abstract "Amyotrophic lateral sclerosis is a neurodegenerative fatal disease. The only drug recognized to increase the survival time is riluzole(RLZ). In animal models, minocycline (MNC) delayed the onset of the disease and increased the survival time (in combination with RLZ). The objective of our work was to study the interactions between RLZ, MNC and the efflux pump p-glycoprotein (p-gp) at the blood-brain barrier. We investigated these two drugs as: (i) p-gp substrates by comparing their brain uptake in CF1 mdr1a (-/-) and mdr1a (+/+) mice, (ii) p-gp modulators by studying their effect on the cerebral uptake of digoxin. mdr1a (-/-) mice showed higher brain uptake of MNC and RLZ than mdr1a (+/+) (in a 1.6- and 1.4-fold, respectively); and in mdr1a (+/+) mice pre-treated with repeated doses of MNC, brain uptake of digoxin was increased. When both drugs were administrated to mdr1a (+/+) mice, MNC increased the brain uptake of RLZ in a 2.1-fold. In conclusion, MNC and RLZ are both p-gp substrates. MNC is also a p-gp inhibitor and increases the brain diffusion of RLZ. In vitro experiments with the GPNT cell line confirmed these results. These interactions should be taken into account in the design of future clinical trials." @default.
• W2081232907 created "2016-06-24" @default.
• W2081232907 creator A5029754351 @default.
• W2081232907 creator A5045076364 @default.
• W2081232907 creator A5049637018 @default.
• W2081232907 creator A5057953137 @default.
• W2081232907 creator A5069426053 @default.
• W2081232907 creator A5071030872 @default.
• W2081232907 date "2007-06-18" @default.
• W2081232907 modified "2023-10-16" @default.
• W2081232907 title "Minocycline and riluzole brain disposition: interactions with p-glycoprotein at the blood?brain barrier" @default.
• W2081232907 cites W113805164 @default.
• W2081232907 cites W128124377 @default.
• W2081232907 cites W1485896673 @default.
• W2081232907 cites W1524061838 @default.
• W2081232907 cites W1603442447 @default.
• W2081232907 cites W1967670520 @default.
• W2081232907 cites W1974309806 @default.
• W2081232907 cites W1986707844 @default.
• W2081232907 cites W1990202885 @default.
• W2081232907 cites W1994609147 @default.
• W2081232907 cites W2001097099 @default.
• W2081232907 cites W2009961226 @default.
• W2081232907 cites W2016756053 @default.
• W2081232907 cites W2036717742 @default.
• W2081232907 cites W2038049372 @default.
• W2081232907 cites W2039184260 @default.
• W2081232907 cites W2040088974 @default.
• W2081232907 cites W2046348685 @default.
• W2081232907 cites W2049135007 @default.
• W2081232907 cites W2058134250 @default.
• W2081232907 cites W2061427816 @default.
• W2081232907 cites W2067906203 @default.
• W2081232907 cites W2067931227 @default.
• W2081232907 cites W2074455856 @default.
• W2081232907 cites W2077826599 @default.
• W2081232907 cites W2081374761 @default.
• W2081232907 cites W2085165928 @default.
• W2081232907 cites W2086138342 @default.
• W2081232907 cites W2086954644 @default.
• W2081232907 cites W2090498230 @default.
• W2081232907 cites W2097079071 @default.
• W2081232907 cites W2107768418 @default.
• W2081232907 cites W2108141803 @default.
• W2081232907 cites W2129200919 @default.
• W2081232907 cites W2136348600 @default.
• W2081232907 cites W2136564762 @default.
• W2081232907 cites W2170125790 @default.
• W2081232907 cites W2247265389 @default.
• W2081232907 cites W2314689571 @default.
• W2081232907 cites W2330440335 @default.
• W2081232907 cites W2512454832 @default.
• W2081232907 cites W4236884331 @default.
• W2081232907 cites W4362218353 @default.
• W2081232907 cites W69871636 @default.
• W2081232907 doi "https://doi.org/10.1111/j.1471-4159.2007.04772.x" @default.
• W2081232907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17635670" @default.
• W2081232907 hasPublicationYear "2007" @default.
• W2081232907 type Work @default.
• W2081232907 sameAs 2081232907 @default.
• W2081232907 citedByCount "39" @default.
• W2081232907 countsByYear W20812329072014 @default.
• W2081232907 countsByYear W20812329072015 @default.
• W2081232907 countsByYear W20812329072016 @default.
• W2081232907 countsByYear W20812329072017 @default.
• W2081232907 countsByYear W20812329072018 @default.
• W2081232907 countsByYear W20812329072019 @default.
• W2081232907 countsByYear W20812329072020 @default.
• W2081232907 countsByYear W20812329072021 @default.
• W2081232907 countsByYear W20812329072022 @default.
• W2081232907 countsByYear W20812329072023 @default.
• W2081232907 crossrefType "journal-article" @default.
• W2081232907 hasAuthorship W2081232907A5029754351 @default.
• W2081232907 hasAuthorship W2081232907A5045076364 @default.
• W2081232907 hasAuthorship W2081232907A5049637018 @default.
• W2081232907 hasAuthorship W2081232907A5057953137 @default.
• W2081232907 hasAuthorship W2081232907A5069426053 @default.
• W2081232907 hasAuthorship W2081232907A5071030872 @default.
• W2081232907 hasBestOaLocation W20812329071 @default.
• W2081232907 hasConcept C126322002 @default.
• W2081232907 hasConcept C133936738 @default.
• W2081232907 hasConcept C185592680 @default.
• W2081232907 hasConcept C202751555 @default.
• W2081232907 hasConcept C2778275353 @default.
• W2081232907 hasConcept C2778402981 @default.
• W2081232907 hasConcept C2778707650 @default.
• W2081232907 hasConcept C2779134260 @default.
• W2081232907 hasConcept C2779319286 @default.
• W2081232907 hasConcept C2780596555 @default.
• W2081232907 hasConcept C501593827 @default.
• W2081232907 hasConcept C529278444 @default.
• W2081232907 hasConcept C55493867 @default.
• W2081232907 hasConcept C71924100 @default.
• W2081232907 hasConcept C98274493 @default.
• W2081232907 hasConceptScore W2081232907C126322002 @default.
• W2081232907 hasConceptScore W2081232907C133936738 @default.
• W2081232907 hasConceptScore W2081232907C185592680 @default.
• W2081232907 hasConceptScore W2081232907C202751555 @default.

• next