FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081254779> ?p ?o ?g. }

• W2081254779 endingPage "630" @default.
• W2081254779 startingPage "619" @default.
• W2081254779 abstract "The sites and mechanisms of the catabolism of atherogenic lipoprotein(a) (Lp(a)) are not well understood. Lp(a) is increased in patients with end-stage renal disease, suggesting a renal catabolism of Lp(a). To gain a better insight into renal handling of Lp(a), we established a heterologous rat model to study the renal catabolism of human Lp(a). Pure human Lp(a) was injected into Wistar rats, and animals were sacrificed at different time points (30 minutes to 24 hours). Intact Lp(a) was cleared from the circulation of injected rats with a half-life time of 14.5 hours. Strong intracellular immunostaining for apolipoprotein(a) (apo(a)) was observed in the cytoplasm of proximal tubular cells after 4, 8, and 24 hours. Apolipoprotein B (apoB) was colocalized with glomerular apo(a) 1 to 8 hours after Lp(a) injection, but renal capillaries and tubules remained negative. No relevant amounts of apo(a) fragments were found in the plasma of rats after injection of Lp(a). During all urine collection periods, apo(a) fragments with molecular weights of 50 to 160 kd were detected in the urine, however. Our results show that human Lp(a) injected into rats accumulates intracellularly in the rat kidney, and apo(a) fragments are excreted in the urine. The kidney apparently plays a major role in fragmentation of Lp(a). Despite the fact that rodents lack endogenous Lp(a), rats injected with human Lp(a) may provide a useful heterologous animal model to study the renal metabolism of Lp(a) further." @default.
• W2081254779 created "2016-06-24" @default.
• W2081254779 creator A5012187712 @default.
• W2081254779 creator A5022477480 @default.
• W2081254779 creator A5040093820 @default.
• W2081254779 creator A5040494349 @default.
• W2081254779 creator A5070005567 @default.
• W2081254779 creator A5070659274 @default.
• W2081254779 creator A5079953015 @default.
• W2081254779 creator A5082836981 @default.
• W2081254779 creator A5089488290 @default.
• W2081254779 date "2001-09-01" @default.
• W2081254779 modified "2023-10-03" @default.
• W2081254779 title "Renal handling of human apolipoprotein(a) and its fragments in the rat" @default.
• W2081254779 cites W1485802716 @default.
• W2081254779 cites W1513540500 @default.
• W2081254779 cites W1566240917 @default.
• W2081254779 cites W1643136010 @default.
• W2081254779 cites W1894209555 @default.
• W2081254779 cites W1967662295 @default.
• W2081254779 cites W1975168532 @default.
• W2081254779 cites W1975573054 @default.
• W2081254779 cites W1980626016 @default.
• W2081254779 cites W1983562504 @default.
• W2081254779 cites W1983762801 @default.
• W2081254779 cites W1985099812 @default.
• W2081254779 cites W1987023197 @default.
• W2081254779 cites W1988007760 @default.
• W2081254779 cites W1993158654 @default.
• W2081254779 cites W1997354164 @default.
• W2081254779 cites W2000203311 @default.
• W2081254779 cites W2001907249 @default.
• W2081254779 cites W2010758833 @default.
• W2081254779 cites W2013493542 @default.
• W2081254779 cites W2014882699 @default.
• W2081254779 cites W2020711578 @default.
• W2081254779 cites W2029442803 @default.
• W2081254779 cites W2053471755 @default.
• W2081254779 cites W2054923994 @default.
• W2081254779 cites W2062899313 @default.
• W2081254779 cites W2071679006 @default.
• W2081254779 cites W2079110191 @default.
• W2081254779 cites W2081157663 @default.
• W2081254779 cites W2093535758 @default.
• W2081254779 cites W2117245915 @default.
• W2081254779 cites W2117988339 @default.
• W2081254779 cites W2124211877 @default.
• W2081254779 cites W2127228103 @default.
• W2081254779 cites W2137707474 @default.
• W2081254779 cites W2166747423 @default.
• W2081254779 cites W2186577366 @default.
• W2081254779 cites W2223917560 @default.
• W2081254779 cites W2276519093 @default.
• W2081254779 cites W2344529588 @default.
• W2081254779 cites W2399722862 @default.
• W2081254779 cites W2418007902 @default.
• W2081254779 cites W4211082323 @default.
• W2081254779 cites W4300646962 @default.
• W2081254779 doi "https://doi.org/10.1053/ajkd.2001.26889" @default.
• W2081254779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11532696" @default.
• W2081254779 hasPublicationYear "2001" @default.
• W2081254779 type Work @default.
• W2081254779 sameAs 2081254779 @default.
• W2081254779 citedByCount "22" @default.
• W2081254779 countsByYear W20812547792012 @default.
• W2081254779 countsByYear W20812547792013 @default.
• W2081254779 countsByYear W20812547792016 @default.
• W2081254779 countsByYear W20812547792017 @default.
• W2081254779 countsByYear W20812547792018 @default.
• W2081254779 countsByYear W20812547792019 @default.
• W2081254779 countsByYear W20812547792021 @default.
• W2081254779 countsByYear W20812547792023 @default.
• W2081254779 crossrefType "journal-article" @default.
• W2081254779 hasAuthorship W2081254779A5012187712 @default.
• W2081254779 hasAuthorship W2081254779A5022477480 @default.
• W2081254779 hasAuthorship W2081254779A5040093820 @default.
• W2081254779 hasAuthorship W2081254779A5040494349 @default.
• W2081254779 hasAuthorship W2081254779A5070005567 @default.
• W2081254779 hasAuthorship W2081254779A5070659274 @default.
• W2081254779 hasAuthorship W2081254779A5079953015 @default.
• W2081254779 hasAuthorship W2081254779A5082836981 @default.
• W2081254779 hasAuthorship W2081254779A5089488290 @default.
• W2081254779 hasConcept C126322002 @default.
• W2081254779 hasConcept C126894567 @default.
• W2081254779 hasConcept C134018914 @default.
• W2081254779 hasConcept C138944611 @default.
• W2081254779 hasConcept C2776104379 @default.
• W2081254779 hasConcept C2778163477 @default.
• W2081254779 hasConcept C2780026642 @default.
• W2081254779 hasConcept C2780091579 @default.
• W2081254779 hasConcept C62231903 @default.
• W2081254779 hasConcept C62746215 @default.
• W2081254779 hasConcept C71924100 @default.
• W2081254779 hasConcept C96942376 @default.
• W2081254779 hasConceptScore W2081254779C126322002 @default.
• W2081254779 hasConceptScore W2081254779C126894567 @default.
• W2081254779 hasConceptScore W2081254779C134018914 @default.
• W2081254779 hasConceptScore W2081254779C138944611 @default.

• next