FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081265872> ?p ?o ?g. }

• W2081265872 endingPage "102" @default.
• W2081265872 startingPage "95" @default.
• W2081265872 abstract "Alpha-lipoic acid (LA) is a commonly used dietary supplement that exerts anti-oxidant and anti-inflammatory effects in vivo and in vitro. We investigated the mechanisms by which LA may confer protection in models of established atherosclerosis. Watanabe heritable hyperlipidemic (WHHL) rabbits were fed with high cholesterol chow for 6 weeks and then randomized to receive either high cholesterol diet alone or combined with LA (20 mg/kg/day) for 12 weeks. Vascular function was analyzed by myography. The effects of LA on T cell migration to chemokine gradients was assessed by Boyden chamber. NF-κB activation was determined by measuring translocation and electrophoresis migration shift assay (EMSA). LA decreased body weight by 15 ± 5% without alterations in lipid parameters. Magnetic Resonance Imaging (MRI) analysis demonstrated that LA reduced atherosclerotic plaques in the abdominal aorta, with morphological analysis revealing reduced lipid and inflammatory cell content. Consistent with its effect on atherosclerosis, LA improved vascular reactivity (decreased constriction to angiotensin II and increased relaxation to acetylcholine and insulin), inhibited NF-κB activation, and decreased oxidative stress and expression of key adhesion molecules in the vasculature. LA reduced T cell content in atherosclerotic plaque in conjunction with decreasing ICAM and CD62L (l-selectin) expression. These effects were confirmed by demonstration of a direct effect of LA in reducing T cell migration in response to CCL5 and SDF-1 and decreasing T cell adhesion to the endothelium by intra-vital microscopy. The present findings offer a mechanistic insight into the therapeutic effects of LA on atherosclerosis." @default.
• W2081265872 created "2016-06-24" @default.
• W2081265872 creator A5018162304 @default.
• W2081265872 creator A5018346155 @default.
• W2081265872 creator A5018782521 @default.
• W2081265872 creator A5022334933 @default.
• W2081265872 creator A5028193901 @default.
• W2081265872 creator A5028219157 @default.
• W2081265872 creator A5036827849 @default.
• W2081265872 creator A5037836263 @default.
• W2081265872 creator A5039009774 @default.
• W2081265872 creator A5058809103 @default.
• W2081265872 creator A5066002755 @default.
• W2081265872 creator A5076488599 @default.
• W2081265872 creator A5087732477 @default.
• W2081265872 date "2010-01-01" @default.
• W2081265872 modified "2023-10-06" @default.
• W2081265872 title "Lipoic acid effects on established atherosclerosis" @default.
• W2081265872 cites W1965696818 @default.
• W2081265872 cites W2001678095 @default.
• W2081265872 cites W2012663953 @default.
• W2081265872 cites W2019305546 @default.
• W2081265872 cites W2024279142 @default.
• W2081265872 cites W2030023299 @default.
• W2081265872 cites W2046728427 @default.
• W2081265872 cites W2060052300 @default.
• W2081265872 cites W2067769137 @default.
• W2081265872 cites W2067995765 @default.
• W2081265872 cites W2068168605 @default.
• W2081265872 cites W2078600320 @default.
• W2081265872 cites W2080373577 @default.
• W2081265872 cites W2084288831 @default.
• W2081265872 cites W2087862991 @default.
• W2081265872 cites W2088208009 @default.
• W2081265872 cites W2089258822 @default.
• W2081265872 cites W2114952735 @default.
• W2081265872 cites W2121487727 @default.
• W2081265872 cites W2127400843 @default.
• W2081265872 cites W2134945522 @default.
• W2081265872 cites W2141443485 @default.
• W2081265872 cites W2156835140 @default.
• W2081265872 cites W4236329425 @default.
• W2081265872 doi "https://doi.org/10.1016/j.lfs.2009.11.009" @default.
• W2081265872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3075920" @default.
• W2081265872 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19944706" @default.
• W2081265872 hasPublicationYear "2010" @default.
• W2081265872 type Work @default.
• W2081265872 sameAs 2081265872 @default.
• W2081265872 citedByCount "62" @default.
• W2081265872 countsByYear W20812658722012 @default.
• W2081265872 countsByYear W20812658722013 @default.
• W2081265872 countsByYear W20812658722014 @default.
• W2081265872 countsByYear W20812658722015 @default.
• W2081265872 countsByYear W20812658722016 @default.
• W2081265872 countsByYear W20812658722017 @default.
• W2081265872 countsByYear W20812658722018 @default.
• W2081265872 countsByYear W20812658722019 @default.
• W2081265872 countsByYear W20812658722020 @default.
• W2081265872 countsByYear W20812658722021 @default.
• W2081265872 countsByYear W20812658722022 @default.
• W2081265872 countsByYear W20812658722023 @default.
• W2081265872 crossrefType "journal-article" @default.
• W2081265872 hasAuthorship W2081265872A5018162304 @default.
• W2081265872 hasAuthorship W2081265872A5018346155 @default.
• W2081265872 hasAuthorship W2081265872A5018782521 @default.
• W2081265872 hasAuthorship W2081265872A5022334933 @default.
• W2081265872 hasAuthorship W2081265872A5028193901 @default.
• W2081265872 hasAuthorship W2081265872A5028219157 @default.
• W2081265872 hasAuthorship W2081265872A5036827849 @default.
• W2081265872 hasAuthorship W2081265872A5037836263 @default.
• W2081265872 hasAuthorship W2081265872A5039009774 @default.
• W2081265872 hasAuthorship W2081265872A5058809103 @default.
• W2081265872 hasAuthorship W2081265872A5066002755 @default.
• W2081265872 hasAuthorship W2081265872A5076488599 @default.
• W2081265872 hasAuthorship W2081265872A5087732477 @default.
• W2081265872 hasBestOaLocation W20812658722 @default.
• W2081265872 hasConcept C123012128 @default.
• W2081265872 hasConcept C126322002 @default.
• W2081265872 hasConcept C13373296 @default.
• W2081265872 hasConcept C134018914 @default.
• W2081265872 hasConcept C1491633281 @default.
• W2081265872 hasConcept C150903083 @default.
• W2081265872 hasConcept C185592680 @default.
• W2081265872 hasConcept C202751555 @default.
• W2081265872 hasConcept C207001950 @default.
• W2081265872 hasConcept C2776151105 @default.
• W2081265872 hasConcept C2776914184 @default.
• W2081265872 hasConcept C2776992346 @default.
• W2081265872 hasConcept C2778163477 @default.
• W2081265872 hasConcept C55493867 @default.
• W2081265872 hasConcept C71924100 @default.
• W2081265872 hasConcept C85789140 @default.
• W2081265872 hasConcept C86803240 @default.
• W2081265872 hasConcept C98274493 @default.
• W2081265872 hasConceptScore W2081265872C123012128 @default.
• W2081265872 hasConceptScore W2081265872C126322002 @default.
• W2081265872 hasConceptScore W2081265872C13373296 @default.
• W2081265872 hasConceptScore W2081265872C134018914 @default.

• next