FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081272021> ?p ?o ?g. }

• W2081272021 endingPage "307" @default.
• W2081272021 startingPage "299" @default.
• W2081272021 abstract "A novel method was developed for studying the diffusion of proteins through poly(D,L-lactide-co-glycolide) (PLG), using a diffusion cell. To develop improved formulations for the controlled release of encapsulated drugs it is important to understand the underlying release mechanisms. When using low-molecular-weight PLG as the release-controlling polymer, diffusion through the pores is often proposed as the main release mechanism. The experimental set-up and method of determining the diffusion coefficient were thoroughly evaluated with regard to the reliability and the influence of the stirring rate. A procedure for spraying thin films of PLG onto a filter, which could be placed in the diffusion cell, was optimized. The method was then applied to the determination of the diffusion coefficient of human growth hormone (hGH) through a PLG film. The results show that the method enables measurements of the diffusion coefficient through the polymer film. Neither the stirring rate nor the concentration of hGH influenced the diffusion coefficient. The diffusion coefficient of hGH through degraded PLG films was 5.0 x 10(-13) m2/s, which is in the range that could be expected, i.e., several orders of magnitude smaller than its the diffusivity in pure water. The reproducibility was good, considering the dynamic properties of PLG, i.e., the difference in diffusion coefficients, at, for example, different stages of degradation and for different compositions of PLG, is expected to be much higher. The variation is probably also present in PLG films used for controlled-release formulations. Although the PLG film contains a large amount of water, a considerable time elapsed before pores of sufficient size formed and diffusion through the film started. In two-component diffusion experiments, the difference in diffusion rate did not correspond to the difference in molecular weight of the solutes, indicating a size exclusion effect. This method can be used to study the effect of changes in the formulation specification. By studying the change in the diffusion coefficient through the degradation process of PLG, or similar polymers, a better understanding of diffusion and, thus, also release mechanisms can be obtained." @default.
• W2081272021 created "2016-06-24" @default.
• W2081272021 creator A5049419653 @default.
• W2081272021 creator A5069790832 @default.
• W2081272021 creator A5072393328 @default.
• W2081272021 date "2005-01-01" @default.
• W2081272021 modified "2023-09-25" @default.
• W2081272021 title "Measurement of Protein Diffusion Through Poly(d,l-Lactide-Co-Glycolide)" @default.
• W2081272021 cites W1971686063 @default.
• W2081272021 cites W1975160666 @default.
• W2081272021 cites W1979343658 @default.
• W2081272021 cites W1989139170 @default.
• W2081272021 cites W1991738016 @default.
• W2081272021 cites W1993187996 @default.
• W2081272021 cites W1993666998 @default.
• W2081272021 cites W1996691875 @default.
• W2081272021 cites W2004667265 @default.
• W2081272021 cites W2012052954 @default.
• W2081272021 cites W2014546288 @default.
• W2081272021 cites W2018888448 @default.
• W2081272021 cites W2025730251 @default.
• W2081272021 cites W2029851542 @default.
• W2081272021 cites W2032888813 @default.
• W2081272021 cites W2041919596 @default.
• W2081272021 cites W2043858252 @default.
• W2081272021 cites W2050861619 @default.
• W2081272021 cites W2059210031 @default.
• W2081272021 cites W2067935619 @default.
• W2081272021 cites W2076311332 @default.
• W2081272021 cites W2078251621 @default.
• W2081272021 doi "https://doi.org/10.1081/pdt-54473" @default.
• W2081272021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15926679" @default.
• W2081272021 hasPublicationYear "2005" @default.
• W2081272021 type Work @default.
• W2081272021 sameAs 2081272021 @default.
• W2081272021 citedByCount "13" @default.
• W2081272021 countsByYear W20812720212012 @default.
• W2081272021 countsByYear W20812720212013 @default.
• W2081272021 countsByYear W20812720212017 @default.
• W2081272021 countsByYear W20812720212018 @default.
• W2081272021 countsByYear W20812720212020 @default.
• W2081272021 crossrefType "journal-article" @default.
• W2081272021 hasAuthorship W2081272021A5049419653 @default.
• W2081272021 hasAuthorship W2081272021A5069790832 @default.
• W2081272021 hasAuthorship W2081272021A5072393328 @default.
• W2081272021 hasConcept C113196181 @default.
• W2081272021 hasConcept C121332964 @default.
• W2081272021 hasConcept C178790620 @default.
• W2081272021 hasConcept C185592680 @default.
• W2081272021 hasConcept C192562407 @default.
• W2081272021 hasConcept C37668627 @default.
• W2081272021 hasConcept C43617362 @default.
• W2081272021 hasConcept C521977710 @default.
• W2081272021 hasConcept C69357855 @default.
• W2081272021 hasConcept C77281830 @default.
• W2081272021 hasConcept C97355855 @default.
• W2081272021 hasConcept C9893847 @default.
• W2081272021 hasConceptScore W2081272021C113196181 @default.
• W2081272021 hasConceptScore W2081272021C121332964 @default.
• W2081272021 hasConceptScore W2081272021C178790620 @default.
• W2081272021 hasConceptScore W2081272021C185592680 @default.
• W2081272021 hasConceptScore W2081272021C192562407 @default.
• W2081272021 hasConceptScore W2081272021C37668627 @default.
• W2081272021 hasConceptScore W2081272021C43617362 @default.
• W2081272021 hasConceptScore W2081272021C521977710 @default.
• W2081272021 hasConceptScore W2081272021C69357855 @default.
• W2081272021 hasConceptScore W2081272021C77281830 @default.
• W2081272021 hasConceptScore W2081272021C97355855 @default.
• W2081272021 hasConceptScore W2081272021C9893847 @default.
• W2081272021 hasIssue "2" @default.
• W2081272021 hasLocation W20812720211 @default.
• W2081272021 hasLocation W20812720212 @default.
• W2081272021 hasOpenAccess W2081272021 @default.
• W2081272021 hasPrimaryLocation W20812720211 @default.
• W2081272021 hasRelatedWork W1518077874 @default.
• W2081272021 hasRelatedWork W1977798251 @default.
• W2081272021 hasRelatedWork W1998408675 @default.
• W2081272021 hasRelatedWork W2005585377 @default.
• W2081272021 hasRelatedWork W2006909078 @default.
• W2081272021 hasRelatedWork W2068548648 @default.
• W2081272021 hasRelatedWork W2112558560 @default.
• W2081272021 hasRelatedWork W2348376825 @default.
• W2081272021 hasRelatedWork W2748952813 @default.
• W2081272021 hasRelatedWork W2899084033 @default.
• W2081272021 hasVolume "10" @default.
• W2081272021 isParatext "false" @default.
• W2081272021 isRetracted "false" @default.
• W2081272021 magId "2081272021" @default.
• W2081272021 workType "article" @default.