FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081279079> ?p ?o ?g. }

• W2081279079 endingPage "e0117718" @default.
• W2081279079 startingPage "e0117718" @default.
• W2081279079 abstract "Diabetic nephropathy is the leading cause of end stage renal disease in the world. Although tremendous efforts have been made, scientists have yet to identify an ideal animal model that can reproduce the characteristics of human diabetic nephropathy. In this study, we hypothesize that taurine insufficiency is a critical risk factor for development of diabetic nephropathy associated with diabetes mellitus. This hypothesis was tested in vivo in TauT heterozygous (TauT+/-) and homozygous (TauT-/-) knockout in C57BL/6 background mice. We have shown that alteration of the TauT gene (also known as SLC6A6) has a substantial effect on the susceptibility to development of extensive diabetic kidney disease in both TauT+/- and TauT-/-mouse models of diabetes. These animals developed histological changes characteristic of human diabetic nephropathy that included glomerulosclerosis, nodular lesions, arteriosclerosis, arteriolar dilation, and tubulointerstitial fibrosis. Immunohistochemical staining of molecular markers of smooth muscle actin, CD34, Ki67 and collagen IV further confirmed these observations. Our results demonstrated that both homozygous and heterozygous TauT gene deletion predispose C57BL/6 mice to develop end-stage diabetic kidney disease, which closely replicates the pathological features of diabetic nephropathy in human diabetic patients." @default.
• W2081279079 created "2016-06-24" @default.
• W2081279079 creator A5017557978 @default.
• W2081279079 creator A5029185764 @default.
• W2081279079 creator A5043161521 @default.
• W2081279079 creator A5059204113 @default.
• W2081279079 creator A5069711734 @default.
• W2081279079 creator A5079427944 @default.
• W2081279079 date "2015-01-28" @default.
• W2081279079 modified "2023-10-01" @default.
• W2081279079 title "Knockout of the TauT Gene Predisposes C57BL/6 Mice to Streptozotocin-Induced Diabetic Nephropathy" @default.
• W2081279079 cites W1968938058 @default.
• W2081279079 cites W1979341432 @default.
• W2081279079 cites W2000792490 @default.
• W2081279079 cites W2004616733 @default.
• W2081279079 cites W2005144348 @default.
• W2081279079 cites W2027839715 @default.
• W2081279079 cites W2060577101 @default.
• W2081279079 cites W2070194162 @default.
• W2081279079 cites W2072366020 @default.
• W2081279079 cites W2074427126 @default.
• W2081279079 cites W2075837574 @default.
• W2081279079 cites W2086710022 @default.
• W2081279079 cites W2088402513 @default.
• W2081279079 cites W2098080124 @default.
• W2081279079 cites W2104687066 @default.
• W2081279079 cites W2110259057 @default.
• W2081279079 cites W2132077174 @default.
• W2081279079 cites W2134975242 @default.
• W2081279079 cites W2139808186 @default.
• W2081279079 cites W2140603115 @default.
• W2081279079 cites W2146179253 @default.
• W2081279079 cites W2147215215 @default.
• W2081279079 cites W2148652246 @default.
• W2081279079 cites W2152618750 @default.
• W2081279079 cites W2171063740 @default.
• W2081279079 cites W2171233986 @default.
• W2081279079 cites W2171857834 @default.
• W2081279079 cites W2188010600 @default.
• W2081279079 cites W2405183840 @default.
• W2081279079 cites W2769264260 @default.
• W2081279079 cites W4241465559 @default.
• W2081279079 doi "https://doi.org/10.1371/journal.pone.0117718" @default.
• W2081279079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4309680" @default.
• W2081279079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25629817" @default.
• W2081279079 hasPublicationYear "2015" @default.
• W2081279079 type Work @default.
• W2081279079 sameAs 2081279079 @default.
• W2081279079 citedByCount "13" @default.
• W2081279079 countsByYear W20812790792016 @default.
• W2081279079 countsByYear W20812790792017 @default.
• W2081279079 countsByYear W20812790792018 @default.
• W2081279079 countsByYear W20812790792019 @default.
• W2081279079 countsByYear W20812790792021 @default.
• W2081279079 countsByYear W20812790792023 @default.
• W2081279079 crossrefType "journal-article" @default.
• W2081279079 hasAuthorship W2081279079A5017557978 @default.
• W2081279079 hasAuthorship W2081279079A5029185764 @default.
• W2081279079 hasAuthorship W2081279079A5043161521 @default.
• W2081279079 hasAuthorship W2081279079A5059204113 @default.
• W2081279079 hasAuthorship W2081279079A5069711734 @default.
• W2081279079 hasAuthorship W2081279079A5079427944 @default.
• W2081279079 hasBestOaLocation W20812790791 @default.
• W2081279079 hasConcept C126322002 @default.
• W2081279079 hasConcept C134018914 @default.
• W2081279079 hasConcept C142724271 @default.
• W2081279079 hasConcept C2777390665 @default.
• W2081279079 hasConcept C2778653478 @default.
• W2081279079 hasConcept C2779280383 @default.
• W2081279079 hasConcept C2779561371 @default.
• W2081279079 hasConcept C2779922275 @default.
• W2081279079 hasConcept C2780091579 @default.
• W2081279079 hasConcept C2780559512 @default.
• W2081279079 hasConcept C2781184683 @default.
• W2081279079 hasConcept C555293320 @default.
• W2081279079 hasConcept C71924100 @default.
• W2081279079 hasConceptScore W2081279079C126322002 @default.
• W2081279079 hasConceptScore W2081279079C134018914 @default.
• W2081279079 hasConceptScore W2081279079C142724271 @default.
• W2081279079 hasConceptScore W2081279079C2777390665 @default.
• W2081279079 hasConceptScore W2081279079C2778653478 @default.
• W2081279079 hasConceptScore W2081279079C2779280383 @default.
• W2081279079 hasConceptScore W2081279079C2779561371 @default.
• W2081279079 hasConceptScore W2081279079C2779922275 @default.
• W2081279079 hasConceptScore W2081279079C2780091579 @default.
• W2081279079 hasConceptScore W2081279079C2780559512 @default.
• W2081279079 hasConceptScore W2081279079C2781184683 @default.
• W2081279079 hasConceptScore W2081279079C555293320 @default.
• W2081279079 hasConceptScore W2081279079C71924100 @default.
• W2081279079 hasIssue "1" @default.
• W2081279079 hasLocation W20812790791 @default.
• W2081279079 hasLocation W20812790792 @default.
• W2081279079 hasLocation W20812790793 @default.
• W2081279079 hasLocation W20812790794 @default.
• W2081279079 hasOpenAccess W2081279079 @default.
• W2081279079 hasPrimaryLocation W20812790791 @default.
• W2081279079 hasRelatedWork W1432224917 @default.
• W2081279079 hasRelatedWork W1995071802 @default.

• next