FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081285846> ?p ?o ?g. }

• W2081285846 endingPage "8315" @default.
• W2081285846 startingPage "8293" @default.
• W2081285846 abstract "Few anti-pigmenting agents have been designed and developed according to their known hyperpigmentation mechanisms and corresponding intracellular signaling cascades. Most anti-pigmenting agents developed so far are mechanistically involved in the interruption of constitutional melanogenic mechanisms by which skin color is maintained at a normal and unstimulated level. Thus, owing to the difficulty of confining topical application to a specific hyperpigmented skin area, potent anti-pigmenting agents capable of attenuating the natural unstimulated pigmentation process have the risk of leading to hypopigmentation. Since intracellular signaling pathways within melanocytes do not function substantially in maintaining normal skin color and are activated only by environmental stimuli such as UV radiation, specifically down-regulating the activation of melanogenesis to the constitutive level would be an appropriate strategy to develop new potent anti-pigmenting agents with a low risk of hypopigmentation. In this article, we review the hyperpigmentation mechanisms and intracellular signaling pathways that lead to the stimulation of melanogenesis. We also discuss a screening and evaluation system to select candidates for new anti-melanogenic substances by focusing on inhibitors of endothelin-1 or stem cell factor-triggered intracellular signaling cascades. From this viewpoint, we show that extracts of the herbs Withania somnifera and Melia toosendan and the natural chemicals Withaferin A and Astaxanthin are new candidates for potent anti-pigmenting substances that avoid the risk of hypopigmentation." @default.
• W2081285846 created "2016-06-24" @default.
• W2081285846 creator A5013511707 @default.
• W2081285846 creator A5087315408 @default.
• W2081285846 date "2014-05-12" @default.
• W2081285846 modified "2023-10-12" @default.
• W2081285846 title "Inhibitors of Intracellular Signaling Pathways that Lead to Stimulated Epidermal Pigmentation: Perspective of Anti-Pigmenting Agents" @default.
• W2081285846 cites W1519510465 @default.
• W2081285846 cites W1577145787 @default.
• W2081285846 cites W1762774727 @default.
• W2081285846 cites W1809259025 @default.
• W2081285846 cites W1861331149 @default.
• W2081285846 cites W1926874813 @default.
• W2081285846 cites W1969785844 @default.
• W2081285846 cites W1977817564 @default.
• W2081285846 cites W1990006711 @default.
• W2081285846 cites W1993540106 @default.
• W2081285846 cites W1993646281 @default.
• W2081285846 cites W1997889534 @default.
• W2081285846 cites W2000890539 @default.
• W2081285846 cites W2001895687 @default.
• W2081285846 cites W2004937289 @default.
• W2081285846 cites W2006059562 @default.
• W2081285846 cites W2009549718 @default.
• W2081285846 cites W2012319148 @default.
• W2081285846 cites W2024771894 @default.
• W2081285846 cites W2032128295 @default.
• W2081285846 cites W2032512715 @default.
• W2081285846 cites W2033837699 @default.
• W2081285846 cites W2040110958 @default.
• W2081285846 cites W2040231284 @default.
• W2081285846 cites W2041362930 @default.
• W2081285846 cites W2047241095 @default.
• W2081285846 cites W2055235209 @default.
• W2081285846 cites W2055972315 @default.
• W2081285846 cites W2056723614 @default.
• W2081285846 cites W2058522093 @default.
• W2081285846 cites W2058736108 @default.
• W2081285846 cites W2062241862 @default.
• W2081285846 cites W2064450926 @default.
• W2081285846 cites W2064850685 @default.
• W2081285846 cites W2078880170 @default.
• W2081285846 cites W2089951482 @default.
• W2081285846 cites W2090475468 @default.
• W2081285846 cites W2092642979 @default.
• W2081285846 cites W2096580997 @default.
• W2081285846 cites W2102845038 @default.
• W2081285846 cites W2109283410 @default.
• W2081285846 cites W2133142994 @default.
• W2081285846 cites W2134890391 @default.
• W2081285846 cites W2168604311 @default.
• W2081285846 cites W337375082 @default.
• W2081285846 cites W4250635458 @default.
• W2081285846 doi "https://doi.org/10.3390/ijms15058293" @default.
• W2081285846 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4057732" @default.
• W2081285846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24823877" @default.
• W2081285846 hasPublicationYear "2014" @default.
• W2081285846 type Work @default.
• W2081285846 sameAs 2081285846 @default.
• W2081285846 citedByCount "45" @default.
• W2081285846 countsByYear W20812858462016 @default.
• W2081285846 countsByYear W20812858462017 @default.
• W2081285846 countsByYear W20812858462018 @default.
• W2081285846 countsByYear W20812858462019 @default.
• W2081285846 countsByYear W20812858462020 @default.
• W2081285846 countsByYear W20812858462021 @default.
• W2081285846 countsByYear W20812858462022 @default.
• W2081285846 countsByYear W20812858462023 @default.
• W2081285846 crossrefType "journal-article" @default.
• W2081285846 hasAuthorship W2081285846A5013511707 @default.
• W2081285846 hasAuthorship W2081285846A5087315408 @default.
• W2081285846 hasBestOaLocation W20812858461 @default.
• W2081285846 hasConcept C16005928 @default.
• W2081285846 hasConcept C2776291823 @default.
• W2081285846 hasConcept C2776728111 @default.
• W2081285846 hasConcept C55493867 @default.
• W2081285846 hasConcept C62478195 @default.
• W2081285846 hasConcept C71924100 @default.
• W2081285846 hasConcept C79879829 @default.
• W2081285846 hasConcept C86803240 @default.
• W2081285846 hasConcept C95444343 @default.
• W2081285846 hasConceptScore W2081285846C16005928 @default.
• W2081285846 hasConceptScore W2081285846C2776291823 @default.
• W2081285846 hasConceptScore W2081285846C2776728111 @default.
• W2081285846 hasConceptScore W2081285846C55493867 @default.
• W2081285846 hasConceptScore W2081285846C62478195 @default.
• W2081285846 hasConceptScore W2081285846C71924100 @default.
• W2081285846 hasConceptScore W2081285846C79879829 @default.
• W2081285846 hasConceptScore W2081285846C86803240 @default.
• W2081285846 hasConceptScore W2081285846C95444343 @default.
• W2081285846 hasIssue "5" @default.
• W2081285846 hasLocation W20812858461 @default.
• W2081285846 hasLocation W20812858462 @default.
• W2081285846 hasLocation W20812858463 @default.
• W2081285846 hasLocation W20812858464 @default.
• W2081285846 hasOpenAccess W2081285846 @default.
• W2081285846 hasPrimaryLocation W20812858461 @default.
• W2081285846 hasRelatedWork W2014883972 @default.

• next