FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081287785> ?p ?o ?g. }

• W2081287785 endingPage "1732" @default.
• W2081287785 startingPage "1731" @default.
• W2081287785 abstract "The study published by Alexander et al. in this issue of Liver Transplantation raises a very interesting and provocative hypothesis that the presence of stainable iron in the hepatic explant of patients undergoing liver transplantation was found to be associated with invasive fungal infection.1 This association could be demonstrated in both univariate and multivariate modeling. The univariate model was consistent with many of the already published risk factors for invasive fungal infection.2-5 However, the authors readily admit that they did not have access to all the risk factors that have been demonstrated to be associated with invasive fungal infection, such as volume of blood transfused, antibiotic use, development of bacteremia, or colonization with fungal species such as candida.2-5 In addition, the authors did not have measures of iron, or transferrin, which might have further elucidated the pathogenesis of invasive fungal infections in these patients. It should also be pointed out that in this group of patients, systemic antifungal prophylaxis was not employed.6 Despite these limitations, I believe the report is extremely valuable and may point out another risk factor that should be considered from both a surveillance and prevention standpoint, namely iron overload. As the authors note, this association has been demonstrated in bone marrow transplantation.7, 8 To my knowledge this is the first report in liver transplantation, although iron overload and the use of iron chelating agents have long been recognized as risk factors for mucormycosis.9 Although the role of iron in the pathogenesis of infections has been well documented, the exact role in the clinical setting remains controversial.10 Iron is an essential component for bacterial virulence in many settings, including animal models of pyelonephritis and enteric infections caused by Yersinia enterocolitica.11, 12 It has also been shown that iron overload may facilitate enhanced viral replication in hepatitis B.13 Conversely, lactoferrin, an iron binding protein present in several body secretions and polymorphonuclear leukocytes granules, has been shown to inhibit herpes simplex, human immunodeficiency virus, and cytomegalovirus infection. Lactoferrin may become saturated in iron overload states, and the inhibitory effects may become reversed.14, 15 Presumably this is one of the mechanisms in which iron overload could predispose patients to infection. Iron does play a role in the function of phagocytes, as well as T and B cells.16 Therefore, it could be postulated that iron excess could inhibit phagocytic function, as well as specific T and B cell function, thus leading to an increased risk for fungal infection. Experimental models of infection have confirmed such physiologic derangements, although data in humans is scarce.17, 18 We, and others, have demonstrated such an effect in hemodialysis patients.19, 20 The authors have brought a very important potential association to the liver transplant community and are to be commended for this hypothesis-generating paper, which will, hopefully, be followed with a prospective study that includes iron markers in serum or plasma, as well as observational studies of other risk factors known to be associated with invasive fungal infection." @default.
• W2081287785 created "2016-06-24" @default.
• W2081287785 creator A5021591786 @default.
• W2081287785 date "2006-01-01" @default.
• W2081287785 modified "2023-10-06" @default.
• W2081287785 title "The potential role for iron overload and fungal infection in liver transplantation" @default.
• W2081287785 cites W1970779248 @default.
• W2081287785 cites W1973939236 @default.
• W2081287785 cites W1986353555 @default.
• W2081287785 cites W1992054309 @default.
• W2081287785 cites W1995337263 @default.
• W2081287785 cites W1996886820 @default.
• W2081287785 cites W2010796095 @default.
• W2081287785 cites W2036210568 @default.
• W2081287785 cites W2044945923 @default.
• W2081287785 cites W2061748969 @default.
• W2081287785 cites W2066136931 @default.
• W2081287785 cites W2112850858 @default.
• W2081287785 cites W2123724558 @default.
• W2081287785 cites W2147333446 @default.
• W2081287785 cites W2158124451 @default.
• W2081287785 cites W2159892946 @default.
• W2081287785 cites W2334794884 @default.
• W2081287785 cites W4322388204 @default.
• W2081287785 doi "https://doi.org/10.1002/lt.20871" @default.
• W2081287785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17133590" @default.
• W2081287785 hasPublicationYear "2006" @default.
• W2081287785 type Work @default.
• W2081287785 sameAs 2081287785 @default.
• W2081287785 citedByCount "8" @default.
• W2081287785 countsByYear W20812877852012 @default.
• W2081287785 countsByYear W20812877852018 @default.
• W2081287785 crossrefType "journal-article" @default.
• W2081287785 hasAuthorship W2081287785A5021591786 @default.
• W2081287785 hasBestOaLocation W20812877851 @default.
• W2081287785 hasConcept C126322002 @default.
• W2081287785 hasConcept C177713679 @default.
• W2081287785 hasConcept C203014093 @default.
• W2081287785 hasConcept C2779443120 @default.
• W2081287785 hasConcept C2779609443 @default.
• W2081287785 hasConcept C2780942790 @default.
• W2081287785 hasConcept C2911091166 @default.
• W2081287785 hasConcept C501593827 @default.
• W2081287785 hasConcept C50440223 @default.
• W2081287785 hasConcept C71924100 @default.
• W2081287785 hasConcept C86803240 @default.
• W2081287785 hasConcept C89423630 @default.
• W2081287785 hasConceptScore W2081287785C126322002 @default.
• W2081287785 hasConceptScore W2081287785C177713679 @default.
• W2081287785 hasConceptScore W2081287785C203014093 @default.
• W2081287785 hasConceptScore W2081287785C2779443120 @default.
• W2081287785 hasConceptScore W2081287785C2779609443 @default.
• W2081287785 hasConceptScore W2081287785C2780942790 @default.
• W2081287785 hasConceptScore W2081287785C2911091166 @default.
• W2081287785 hasConceptScore W2081287785C501593827 @default.
• W2081287785 hasConceptScore W2081287785C50440223 @default.
• W2081287785 hasConceptScore W2081287785C71924100 @default.
• W2081287785 hasConceptScore W2081287785C86803240 @default.
• W2081287785 hasConceptScore W2081287785C89423630 @default.
• W2081287785 hasIssue "12" @default.
• W2081287785 hasLocation W20812877851 @default.
• W2081287785 hasLocation W20812877852 @default.
• W2081287785 hasOpenAccess W2081287785 @default.
• W2081287785 hasPrimaryLocation W20812877851 @default.
• W2081287785 hasRelatedWork W2372353835 @default.
• W2081287785 hasRelatedWork W2431095629 @default.
• W2081287785 hasRelatedWork W2920328101 @default.
• W2081287785 hasRelatedWork W2987422743 @default.
• W2081287785 hasRelatedWork W3032540778 @default.
• W2081287785 hasRelatedWork W3036143884 @default.
• W2081287785 hasRelatedWork W3048868682 @default.
• W2081287785 hasRelatedWork W3094511205 @default.
• W2081287785 hasRelatedWork W4232734559 @default.
• W2081287785 hasRelatedWork W4249385634 @default.
• W2081287785 hasVolume "12" @default.
• W2081287785 isParatext "false" @default.
• W2081287785 isRetracted "false" @default.
• W2081287785 magId "2081287785" @default.
• W2081287785 workType "article" @default.