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- W2081288911 abstract "Localised scleroderma (LScl) is a connective tissue disorder usually limited to the skin and subcutaneous tissue, but it sometimes affects the muscle beneath the cutaneous lesions. The absence of Raynaud's phenomenon, acrosclerosis, and internal organ involvement differentiates LScl from systemic sclerosis (SSc).1 LScl has been reported to be accompanied by a variety of abnormal immune reactions, such as the presence of antinuclear antibody, rheumatoid factor, anti-single-stranded DNA antibody (anti-ssDNA), and antihistone antibody.2-5 In our laboratory an indirect immunofluorescent study showed nucleolar staining in the serum samples of some patients with LScl. Although autoantibodies to nucleolar antigens have been well described in patients with SSc,6 7 these antibodies have not been determined in patients with LScl, and the incidence of anti-U3 snRNP antibodies has not been described previously. In this study we investigated the prevalence of anti-U3 snRNP antibodies using RNA immunoprecipitation,8 and examined the clinical and laboratory features of patients with LScl. In addition, we examined the serum samples …" @default.
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- W2081288911 date "2001-12-01" @default.
- W2081288911 modified "2023-10-13" @default.
- W2081288911 title "Anti-U3 snRNP antibodies in localised scleroderma" @default.
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- W2081288911 doi "https://doi.org/10.1136/ard.60.12.1157" @default.
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