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• W2081296998 abstract "To isolate environmental bacteria capable of transforming fluoroquinolones to inactive molecules.Bacteria were isolated from the aerobic liquor of a wastewater treatment plant on a medium containing norfloxacin (100 mg l(-1)). Twenty-two isolates were highly resistant (minimal inhibitory concentration: 6.25-200 microg ml(-1)) to five fluoroquinolones and six of them were positive by PCR amplification for the aminoglycoside resistance gene aac(6')-Ib. Of these, only Escherichia coli strain LR09 had the ciprofloxacin-acetylating variant gene aac(6')-Ib-cr; HPLC and mass spectrometry showed that this strain transformed both ciprofloxacin and norfloxacin by N-acetylation. This bacterium also had mutations in the quinolone-resistance determining regions of the gyrA and parC genes.An E. coli isolate from wastewater, which possessed at least two distinct fluoroquinolone resistance mechanisms, inactivated ciprofloxacin and norfloxacin by N-acetylation.This is the first report of N-acetylation of fluoroquinolones by an aac(6')-Ib-cr-containing bacterium from an environmental source." @default.
• W2081296998 created "2016-06-24" @default.
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• W2081296998 date "2009-02-01" @default.
• W2081296998 modified "2023-09-27" @default.
• W2081296998 title "Acetylation of fluoroquinolone antimicrobial agents by an<i>Escherichia coli</i>strain isolated from a municipal wastewater treatment plant" @default.
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• W2081296998 doi "https://doi.org/10.1111/j.1365-2672.2008.04026.x" @default.
• W2081296998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19200322" @default.
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