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• W2081307963 abstract "Biopsies from human localized cutaneous lesions (LCL n = 7) or disseminated lesions (DL n = 8) cases were characterized according to cellular infiltration,frequency of cytokine (IFN-<FONT FACE=Symbol>g</font>, TNF-alpha) or iNOS enzyme producing cells. LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage. DL is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue damage. We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN-gamma expression. In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells. Frequency of TNF-alpha and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and DL. Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher frequency of IFN-gamma producing cells, as well as its possible counteraction by infiltrated B cells and hence possible humoral immune response in situ." @default.
• W2081307963 created "2016-06-24" @default.
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• W2081307963 date "2002-10-01" @default.
• W2081307963 modified "2023-10-16" @default.
• W2081307963 title "B-cell infiltration and frequency of cytokine producing cells differ between localized and disseminated human cutaneous leishmaniases" @default.
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• W2081307963 doi "https://doi.org/10.1590/s0074-02762002000700009" @default.
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