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• W2081323278 abstract "Resistin has been shown to cause insulin resistance and to impair glucose tolerance in rodents, but in humans its physiological role still remains elusive. The aim of this study was to examine whether resistin mRNA expression in human peripheral mononuclear cells (PBMCs) and its corresponding plasma levels are altered in type 2 diabetes. Resistin mRNA levels were easily detectable in human PBMC, and found to be higher in DM2 compared to healthy women<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.05</mml:mn></mml:mrow><mml:mo>)</mml:mo></mml:mrow></mml:math>. Similarly, mononuclear mRNA levels of the proinflammatory cytokines IL-1<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>, TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>, and IL-6 were all significantly higher in DM2 compared to control women<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>.001</mml:mn></mml:mrow><mml:mo>)</mml:mo></mml:mrow></mml:math>. The corresponding plasma resistin levels were slightly, but not significantly, increased in DM2 women<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mo>(</mml:mo><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.051</mml:mn></mml:mrow><mml:mo>)</mml:mo></mml:mrow></mml:math>, and overall, they correlated significantly with BMI (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.406</mml:mn></mml:mrow></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.010</mml:mn></mml:mrow></mml:math>) and waist circumference (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.516</mml:mn></mml:mrow></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>.003</mml:mn></mml:mrow></mml:math>), but not with fasting insulin levels or HOMA-IR. Resistin mRNA expression is increased in PBMC from DM2 women, together with increased expression of the inflammatory cytokines IL-1<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>β</mml:mi></mml:math>, TNF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mi>α</mml:mi></mml:math>, and IL-6, independent of obesity. These results suggest that resistin and cytokines might contribute to the low-grade inflammation and the increased atherogenic risk observed in these patients." @default.
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• W2081323278 date "2008-01-01" @default.
• W2081323278 modified "2023-09-26" @default.
• W2081323278 title "Peripheral Mononuclear Cell Resistin mRNA Expression Is Increased in Type 2 Diabetic Women" @default.
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• W2081323278 doi "https://doi.org/10.1155/2008/892864" @default.
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