FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081337060> ?p ?o ?g. }

• W2081337060 endingPage "143" @default.
• W2081337060 startingPage "133" @default.
• W2081337060 abstract "We have previously reported the formation and characterization of poly(ethylene glycol) (PEG)-coated and chitosan (CS)-coated lipid nanoparticles. In the present work our goal was to study the interaction of these surface-modified lipid nanoparticles with Caco-2 cells and to evaluate the potential of these nanostructures as oral delivery systems for salmon calcitonin (sCT). The interaction of rhodamine-loaded nanoparticles with the Caco-2 cell monolayers was evaluated quantitatively and qualitatively by confocal laser scanning microscopy and fluorimetry, respectively. The ability of these nanoparticles to reversibly enhance the transport of hydrophilic macromolecules through the monolayers was investigated by measuring the transepithelial electric resistance and the permeability to Texas Red-dextran. Finally, in vivo studies of the response to sCT-loaded nanoparticles were performed in rats. The results showed that the association of rhodamine-loaded nanoparticles to the Caco-2 cell monolayer was independent of the surface coating of the nanoparticles (CS-coated versus PEG-coated nanoparticles). However, while PEG-coated nanoparticles did not affect the permeability of Caco-2 monolayers, CS-coated nanoparticles produced a dose-dependent reduction in the transepithelial electric resistance, simultaneously to an enhanced dextran transport. The results obtained following oral administration of sCT-loaded CS-coated nanoparticles to rats showed a significant and prolonged reduction in the serum calcium levels as compared to those obtained for control (sCT solution). In contrast, the hypocalcemic response of sCT-loaded PEG-coated nanoparticles was not significantly different of that provided by the control (sCT solution). Therefore, these results indicate that the surface composition of the particles is a key factor in the improvement of the efficiency of oral sCT formulations. Moreover, the encouraging results obtained for CS-coated nanoparticles underline their potential as carriers for peptide delivery." @default.
• W2081337060 created "2016-06-24" @default.
• W2081337060 creator A5015194083 @default.
• W2081337060 creator A5031298057 @default.
• W2081337060 creator A5057154172 @default.
• W2081337060 creator A5073593647 @default.
• W2081337060 date "2005-05-01" @default.
• W2081337060 modified "2023-10-15" @default.
• W2081337060 title "A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery" @default.
• W2081337060 cites W1494872149 @default.
• W2081337060 cites W1498725963 @default.
• W2081337060 cites W1506654534 @default.
• W2081337060 cites W1541781779 @default.
• W2081337060 cites W1553373140 @default.
• W2081337060 cites W1664986234 @default.
• W2081337060 cites W1967555973 @default.
• W2081337060 cites W1968819874 @default.
• W2081337060 cites W1973153566 @default.
• W2081337060 cites W1975133899 @default.
• W2081337060 cites W1982619942 @default.
• W2081337060 cites W1993722110 @default.
• W2081337060 cites W1997955648 @default.
• W2081337060 cites W1999934318 @default.
• W2081337060 cites W2011528661 @default.
• W2081337060 cites W2033190444 @default.
• W2081337060 cites W2039046378 @default.
• W2081337060 cites W2043502318 @default.
• W2081337060 cites W2047796161 @default.
• W2081337060 cites W2063276424 @default.
• W2081337060 cites W2067516397 @default.
• W2081337060 cites W2087479668 @default.
• W2081337060 cites W2092607934 @default.
• W2081337060 cites W2165137027 @default.
• W2081337060 cites W22959835 @default.
• W2081337060 cites W37840549 @default.
• W2081337060 cites W2088581894 @default.
• W2081337060 cites W2109517031 @default.
• W2081337060 doi "https://doi.org/10.1016/j.ejps.2005.02.008" @default.
• W2081337060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15854809" @default.
• W2081337060 hasPublicationYear "2005" @default.
• W2081337060 type Work @default.
• W2081337060 sameAs 2081337060 @default.
• W2081337060 citedByCount "159" @default.
• W2081337060 countsByYear W20813370602012 @default.
• W2081337060 countsByYear W20813370602013 @default.
• W2081337060 countsByYear W20813370602014 @default.
• W2081337060 countsByYear W20813370602015 @default.
• W2081337060 countsByYear W20813370602016 @default.
• W2081337060 countsByYear W20813370602017 @default.
• W2081337060 countsByYear W20813370602018 @default.
• W2081337060 countsByYear W20813370602019 @default.
• W2081337060 countsByYear W20813370602020 @default.
• W2081337060 countsByYear W20813370602021 @default.
• W2081337060 countsByYear W20813370602022 @default.
• W2081337060 countsByYear W20813370602023 @default.
• W2081337060 crossrefType "journal-article" @default.
• W2081337060 hasAuthorship W2081337060A5015194083 @default.
• W2081337060 hasAuthorship W2081337060A5031298057 @default.
• W2081337060 hasAuthorship W2081337060A5057154172 @default.
• W2081337060 hasAuthorship W2081337060A5073593647 @default.
• W2081337060 hasConcept C10138342 @default.
• W2081337060 hasConcept C12554922 @default.
• W2081337060 hasConcept C127413603 @default.
• W2081337060 hasConcept C13245373 @default.
• W2081337060 hasConcept C13965031 @default.
• W2081337060 hasConcept C155672457 @default.
• W2081337060 hasConcept C162324750 @default.
• W2081337060 hasConcept C171250308 @default.
• W2081337060 hasConcept C178790620 @default.
• W2081337060 hasConcept C185592680 @default.
• W2081337060 hasConcept C192562407 @default.
• W2081337060 hasConcept C2776964284 @default.
• W2081337060 hasConcept C2777516009 @default.
• W2081337060 hasConcept C2779732960 @default.
• W2081337060 hasConcept C2779820397 @default.
• W2081337060 hasConcept C2780020223 @default.
• W2081337060 hasConcept C42360764 @default.
• W2081337060 hasConcept C54400483 @default.
• W2081337060 hasConcept C55493867 @default.
• W2081337060 hasConcept C7070889 @default.
• W2081337060 hasConcept C86803240 @default.
• W2081337060 hasConceptScore W2081337060C10138342 @default.
• W2081337060 hasConceptScore W2081337060C12554922 @default.
• W2081337060 hasConceptScore W2081337060C127413603 @default.
• W2081337060 hasConceptScore W2081337060C13245373 @default.
• W2081337060 hasConceptScore W2081337060C13965031 @default.
• W2081337060 hasConceptScore W2081337060C155672457 @default.
• W2081337060 hasConceptScore W2081337060C162324750 @default.
• W2081337060 hasConceptScore W2081337060C171250308 @default.
• W2081337060 hasConceptScore W2081337060C178790620 @default.
• W2081337060 hasConceptScore W2081337060C185592680 @default.
• W2081337060 hasConceptScore W2081337060C192562407 @default.
• W2081337060 hasConceptScore W2081337060C2776964284 @default.
• W2081337060 hasConceptScore W2081337060C2777516009 @default.
• W2081337060 hasConceptScore W2081337060C2779732960 @default.
• W2081337060 hasConceptScore W2081337060C2779820397 @default.
• W2081337060 hasConceptScore W2081337060C2780020223 @default.
• W2081337060 hasConceptScore W2081337060C42360764 @default.

• next