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• W2081341888 abstract "Obesity has been implicated in several diseases, including cancer; however, the relationship of obesity and susceptibility to ultraviolet (UV) radiation-caused skin diseases has not been investigated. As UV-induced oxidative stress has been implicated in several skin diseases, we assessed the role of obesity on UVB-induced oxidative stress in genetically obese Lepob/Lepob (leptin-deficient) mice. Here, we report that chronic exposure to UVB (120 mJ/cm2) resulted in greater oxidative stress in the skin of obese mice in terms of higher levels of H2O2 and NO production, photo-oxidative damage of lipids and proteins, and greater depletion of antioxidant defense enzymes, like glutathione, glutathione peroxidase, and catalase. As UV-induced oxidative stress mediates activation of MAPK and NF-κB signaling pathways, we determined the effects of UVB on these pathways in obese mice. Exposure of obese mice to UVB resulted in phosphorylation of ERK1/2, JNK, and p38 proteins of the MAPK family. Compared to wild-type mice, the obese mice exhibited higher levels of phosphorylation of these proteins, greater activation of NF-κB/p65, and higher levels of circulating proinflammatory cytokines, including TNF-α, IL-1β and IL-6, on UVB irradiation. Taking these results together, our study suggests for the first time that obesity in mice is associated with greater susceptibility to UVB-induced oxidative stress and therefore may be a risk factor for skin diseases associated with UVB-induced oxidative stress." @default.
• W2081341888 created "2016-06-24" @default.
• W2081341888 creator A5004079933 @default.
• W2081341888 creator A5036743590 @default.
• W2081341888 date "2007-01-01" @default.
• W2081341888 modified "2023-10-14" @default.
• W2081341888 title "Obesity increases the risk of UV radiation-induced oxidative stress and activation of MAPK and NF-κB signaling" @default.
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• W2081341888 doi "https://doi.org/10.1016/j.freeradbiomed.2006.10.049" @default.
• W2081341888 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1805635" @default.
• W2081341888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17189835" @default.
• W2081341888 hasPublicationYear "2007" @default.
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