FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081342662> ?p ?o ?g. }

• W2081342662 endingPage "6682" @default.
• W2081342662 startingPage "6670" @default.
• W2081342662 abstract "Mincle, the macrophage-inducible C-type lectin also known as CLEC-4E, binds to the mycobacterial glycolipid trehalose dimycolate and initiates a signaling cascade by serving as a receptor for Mycobacterium tuberculosis and other pathogenic mycobacterial species. Studies of the biological functions of human mincle often rely on mouse models, based on the assumption that the biological properties of the mouse receptor mimic those of the human protein. Experimental support for this assumption has been obtained by expression of the carbohydrate-recognition domain of mouse mincle and characterization of its interaction with small molecule analogs of trehalose dimycolate. The results confirm that the ligand-binding properties of mouse mincle closely parallel those of the human receptor. These findings are consistent with the conservation of key amino acid residues that have been shown to form the ligand-binding site in human and cow mincle. Sequence alignment reveals that these residues are conserved in a wide range of mammalian species, suggesting that mincle has a conserved function in binding ligands that may include endogenous mammalian glycans or pathogen glycans in addition to trehalose dimycolate." @default.
• W2081342662 created "2016-06-24" @default.
• W2081342662 creator A5009745231 @default.
• W2081342662 creator A5025946077 @default.
• W2081342662 creator A5029015760 @default.
• W2081342662 creator A5076728306 @default.
• W2081342662 creator A5086277029 @default.
• W2081342662 date "2015-04-15" @default.
• W2081342662 modified "2023-09-27" @default.
• W2081342662 title "Mouse Mincle: Characterization as a Model for Human Mincle and Evolutionary Implications" @default.
• W2081342662 cites W130118969 @default.
• W2081342662 cites W1563750046 @default.
• W2081342662 cites W1602886661 @default.
• W2081342662 cites W1735091417 @default.
• W2081342662 cites W1893651774 @default.
• W2081342662 cites W1972714115 @default.
• W2081342662 cites W1989459539 @default.
• W2081342662 cites W2027562913 @default.
• W2081342662 cites W2034867322 @default.
• W2081342662 cites W2036260143 @default.
• W2081342662 cites W2037400650 @default.
• W2081342662 cites W2037459277 @default.
• W2081342662 cites W2043173265 @default.
• W2081342662 cites W2061551128 @default.
• W2081342662 cites W2062200101 @default.
• W2081342662 cites W2065429310 @default.
• W2081342662 cites W2074795280 @default.
• W2081342662 cites W2085357178 @default.
• W2081342662 cites W2100837269 @default.
• W2081342662 cites W2115227037 @default.
• W2081342662 cites W2122447210 @default.
• W2081342662 cites W2145407927 @default.
• W2081342662 cites W2158830057 @default.
• W2081342662 cites W2161051601 @default.
• W2081342662 cites W2163350708 @default.
• W2081342662 cites W2168222911 @default.
• W2081342662 cites W2500219704 @default.
• W2081342662 doi "https://doi.org/10.3390/molecules20046670" @default.
• W2081342662 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4533885" @default.
• W2081342662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25884549" @default.
• W2081342662 hasPublicationYear "2015" @default.
• W2081342662 type Work @default.
• W2081342662 sameAs 2081342662 @default.
• W2081342662 citedByCount "23" @default.
• W2081342662 countsByYear W20813426622015 @default.
• W2081342662 countsByYear W20813426622016 @default.
• W2081342662 countsByYear W20813426622017 @default.
• W2081342662 countsByYear W20813426622018 @default.
• W2081342662 countsByYear W20813426622020 @default.
• W2081342662 countsByYear W20813426622021 @default.
• W2081342662 countsByYear W20813426622022 @default.
• W2081342662 countsByYear W20813426622023 @default.
• W2081342662 crossrefType "journal-article" @default.
• W2081342662 hasAuthorship W2081342662A5009745231 @default.
• W2081342662 hasAuthorship W2081342662A5025946077 @default.
• W2081342662 hasAuthorship W2081342662A5029015760 @default.
• W2081342662 hasAuthorship W2081342662A5076728306 @default.
• W2081342662 hasAuthorship W2081342662A5086277029 @default.
• W2081342662 hasBestOaLocation W20813426621 @default.
• W2081342662 hasConcept C106257327 @default.
• W2081342662 hasConcept C108625454 @default.
• W2081342662 hasConcept C14036430 @default.
• W2081342662 hasConcept C170493617 @default.
• W2081342662 hasConcept C206212055 @default.
• W2081342662 hasConcept C22222904 @default.
• W2081342662 hasConcept C2778452849 @default.
• W2081342662 hasConcept C2780758401 @default.
• W2081342662 hasConcept C55493867 @default.
• W2081342662 hasConcept C70721500 @default.
• W2081342662 hasConcept C86803240 @default.
• W2081342662 hasConcept C95444343 @default.
• W2081342662 hasConceptScore W2081342662C106257327 @default.
• W2081342662 hasConceptScore W2081342662C108625454 @default.
• W2081342662 hasConceptScore W2081342662C14036430 @default.
• W2081342662 hasConceptScore W2081342662C170493617 @default.
• W2081342662 hasConceptScore W2081342662C206212055 @default.
• W2081342662 hasConceptScore W2081342662C22222904 @default.
• W2081342662 hasConceptScore W2081342662C2778452849 @default.
• W2081342662 hasConceptScore W2081342662C2780758401 @default.
• W2081342662 hasConceptScore W2081342662C55493867 @default.
• W2081342662 hasConceptScore W2081342662C70721500 @default.
• W2081342662 hasConceptScore W2081342662C86803240 @default.
• W2081342662 hasConceptScore W2081342662C95444343 @default.
• W2081342662 hasFunder F4320334629 @default.
• W2081342662 hasIssue "4" @default.
• W2081342662 hasLocation W20813426621 @default.
• W2081342662 hasLocation W20813426622 @default.
• W2081342662 hasLocation W20813426623 @default.
• W2081342662 hasLocation W20813426624 @default.
• W2081342662 hasLocation W20813426625 @default.
• W2081342662 hasOpenAccess W2081342662 @default.
• W2081342662 hasPrimaryLocation W20813426621 @default.
• W2081342662 hasRelatedWork W2081342662 @default.
• W2081342662 hasRelatedWork W2139146726 @default.
• W2081342662 hasRelatedWork W2418189310 @default.
• W2081342662 hasRelatedWork W2920003033 @default.
• W2081342662 hasRelatedWork W3164345852 @default.
• W2081342662 hasRelatedWork W3170168316 @default.

• next