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• W2081346742 abstract "A variety of successful transcription and translation engineering strategies implemented during the past decade have driven the specific productivity of mammalian cells to an apparent limit. Restricted post-translation competence has since been considered the major bottleneck preventing mammalian cells from fully exploiting their physiologic production capacity in a biopharmaceutical manufacturing scenario. Through ectopic expression of the human transcription factor Xbp1 (X-box-binding-protein 1), evolved to manage plasma cell differentiation and coordinate the unfolded protein response, we have specifically expanded the endoplasmic reticulum and the Golgi of transgenic Chinese hamster ovary (CHO-K1)-derived cell lines with a resulting increase in overall production capacity. Xbp-1-based engineering of secretory bottlenecks was compatible with a variety of different promoter–product gene configurations suggesting that Xbp-1 induces generic production increases in CHO-K1 cell derivatives. Secretion engineering, illustrated here by Xbp1-based reprogramming of the post-translational processing machinery, provides a first insight into mastering a major system bottleneck which impacts biopharmaceutical manufacturing of secreted protein therapeutics." @default.
• W2081346742 created "2016-06-24" @default.
• W2081346742 creator A5082252506 @default.
• W2081346742 creator A5086083218 @default.
• W2081346742 date "2006-05-01" @default.
• W2081346742 modified "2023-10-07" @default.
• W2081346742 title "Xbp1-based engineering of secretory capacity enhances the productivity of Chinese hamster ovary cells" @default.
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• W2081346742 doi "https://doi.org/10.1016/j.ymben.2006.01.006" @default.
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