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• W2081347365 endingPage "e33260" @default.
• W2081347365 startingPage "e33260" @default.
• W2081347365 abstract "Approach or avoidance behaviors are accompanied by perceptual vigilance for, affective reactivity to and behavioral predisposition towards rewarding or punitive stimuli, respectively. We detected three subpopulations of C57BL/6J mice that responded with avoiding, balancing or approaching behaviors not induced by any experimental manipulation but spontaneously displayed in an approach/avoidance conflict task. Although the detailed neuronal mechanisms underlying the balancing between approach and avoidance are not fully clarified, there is growing evidence that endocannabinoid system (ECS) plays a critical role in the control of these balancing actions. The sensitivity of dorsal striatal synapses to the activation of cannabinoid CB1 receptors was investigated in the subpopulations of spontaneously avoiding, balancing or approaching mice. Avoiding animals displayed decreased control of CB1 receptors on GABAergic striatal transmission and in parallel increase of behavioral inhibition. Conversely, approaching animals exhibited increased control of CB1 receptors and in parallel increase of explorative behavior. Balancing animals reacted with balanced responses between approach and avoidance patterns. Treating avoiding animals with URB597 (fatty acid amide hydrolase inhibitor) or approaching animals with AM251 (CB1 receptor inverse agonist) reverted their respective behavioral and electrophysiological patterns. Therefore, enhanced or reduced CB1-mediated control on dorsal striatal transmission represents the synaptic hallmark of the approach or avoidance behavior, respectively. Thus, the opposite spontaneous responses to conflicting stimuli are modulated by a different involvement of endocannabinoid signaling of dorsal striatal neurons in the range of temperamental traits related to individual differences." @default.
• W2081347365 created "2016-06-24" @default.
• W2081347365 creator A5001899447 @default.
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• W2081347365 creator A5034688725 @default.
• W2081347365 creator A5041223053 @default.
• W2081347365 creator A5079049956 @default.
• W2081347365 date "2012-03-08" @default.
• W2081347365 modified "2023-10-15" @default.
• W2081347365 title "Differences in Spontaneously Avoiding or Approaching Mice Reflect Differences in CB1-Mediated Signaling of Dorsal Striatal Transmission" @default.
• W2081347365 cites W1483388411 @default.
• W2081347365 cites W1510896541 @default.
• W2081347365 cites W1524098192 @default.
• W2081347365 cites W1524480852 @default.
• W2081347365 cites W1592286181 @default.
• W2081347365 cites W1596886225 @default.
• W2081347365 cites W1905669859 @default.
• W2081347365 cites W1967329061 @default.
• W2081347365 cites W1974214885 @default.
• W2081347365 cites W1977781430 @default.
• W2081347365 cites W1978739151 @default.
• W2081347365 cites W1981147834 @default.
• W2081347365 cites W1981654563 @default.
• W2081347365 cites W1985655629 @default.
• W2081347365 cites W1987996838 @default.
• W2081347365 cites W1996124584 @default.
• W2081347365 cites W2007064781 @default.
• W2081347365 cites W2008857744 @default.
• W2081347365 cites W2011004475 @default.
• W2081347365 cites W2011836533 @default.
• W2081347365 cites W2013732522 @default.
• W2081347365 cites W2014163596 @default.
• W2081347365 cites W2014729506 @default.
• W2081347365 cites W2017543199 @default.
• W2081347365 cites W2018305067 @default.
• W2081347365 cites W2021320024 @default.
• W2081347365 cites W2028299419 @default.
• W2081347365 cites W2029181309 @default.
• W2081347365 cites W2041123835 @default.
• W2081347365 cites W2042587343 @default.
• W2081347365 cites W2043356587 @default.
• W2081347365 cites W2043828632 @default.
• W2081347365 cites W2045088017 @default.
• W2081347365 cites W2051301373 @default.
• W2081347365 cites W2055871399 @default.
• W2081347365 cites W2056637988 @default.
• W2081347365 cites W2061994450 @default.
• W2081347365 cites W2062367401 @default.
• W2081347365 cites W2066848874 @default.
• W2081347365 cites W2067214410 @default.
• W2081347365 cites W2072061544 @default.
• W2081347365 cites W2074370892 @default.
• W2081347365 cites W2074596450 @default.
• W2081347365 cites W2077269794 @default.
• W2081347365 cites W2080649553 @default.
• W2081347365 cites W2082376482 @default.
• W2081347365 cites W2084331056 @default.
• W2081347365 cites W2091726345 @default.
• W2081347365 cites W2096012985 @default.
• W2081347365 cites W2096287345 @default.
• W2081347365 cites W2099878623 @default.
• W2081347365 cites W2103789151 @default.
• W2081347365 cites W2104070301 @default.
• W2081347365 cites W2107405599 @default.
• W2081347365 cites W2110601854 @default.
• W2081347365 cites W2110941726 @default.
• W2081347365 cites W2112337921 @default.
• W2081347365 cites W2112996418 @default.
• W2081347365 cites W2116562654 @default.
• W2081347365 cites W2119826244 @default.
• W2081347365 cites W2122487138 @default.
• W2081347365 cites W2124600498 @default.
• W2081347365 cites W2126187943 @default.
• W2081347365 cites W2126448703 @default.
• W2081347365 cites W2126766019 @default.
• W2081347365 cites W2127384831 @default.
• W2081347365 cites W2128957544 @default.
• W2081347365 cites W2130141507 @default.
• W2081347365 cites W2133291978 @default.
• W2081347365 cites W2140217254 @default.
• W2081347365 cites W2142544832 @default.
• W2081347365 cites W2143117643 @default.
• W2081347365 cites W2150840196 @default.
• W2081347365 cites W2158530645 @default.
• W2081347365 cites W2161688011 @default.
• W2081347365 cites W2164142910 @default.
• W2081347365 cites W2166199263 @default.
• W2081347365 cites W2166425651 @default.
• W2081347365 cites W4233520978 @default.
• W2081347365 cites W4241363254 @default.
• W2081347365 cites W4376848249 @default.
• W2081347365 cites W51456614 @default.
• W2081347365 doi "https://doi.org/10.1371/journal.pone.0033260" @default.
• W2081347365 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3297636" @default.
• W2081347365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22413007" @default.
• W2081347365 hasPublicationYear "2012" @default.

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