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• W2081361261 abstract "Abstract Although systemic immune reactivity to 65-kD mycobacterial hsp65 (m-hsp65) has been shown previously in Behçet's disease (BD), local immune response was not investigated. We studied anti-m-hsp65 IgG, IgM and IgA antibodies in the serum and cerebrospinal fluid (CSF) of 25 BD patients with cerebral parenchymal involvement (p-NBD), seven BD patients with intracranial hypertension (ih-NBD), eight BD patients without central nervous system (CNS) involvement, 30 patients with multiple sclerosis (MS) and 24 patients with non-inflammatory CNS disorders (NIC). Significantly higher CSF IgG responses were detected in p-NBD patients (ELISA ratio 1.3 ± 0.9) compared with NIC (0.7 ± 0.4, P &lt; 0.01). In p-NBD patients' IgG, IgM or IgA CSF anti-m-hsp65 positivity rate was 48% (12/25); this was significantly higher when compared with MS (3/30; P &lt; 0.03) and NIC (3/24; P &lt; 0.01). CSF anti-m-hsp65 IgG ratios correlated with the duration of BD (r = 0.4, P &lt; 0.04) but not with the duration of neurological involvement. Serum IgM and IgA responses were elevated in ih-NBD, suggesting a different type of involvement than p-NBD. These results implicate an increased local humoral response to m-hsp65 in the CSF of p-NBD patients, which might be related to the pathogenesis of neurological involvement." @default.
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• W2081361261 date "1998-07-01" @default.
• W2081361261 modified "2023-10-18" @default.
• W2081361261 title "Humoral immune response to mycobacterial heat shock protein (hsp)65 in the cerebrospinal fluid of neuro-Behçet patients" @default.
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• W2081361261 doi "https://doi.org/10.1046/j.1365-2249.1998.00620.x" @default.
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