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• W2081363417 endingPage "270" @default.
• W2081363417 startingPage "243" @default.
• W2081363417 abstract "Several morphological lesions have been proposed that may act as potential precursor lesions of prostate cancer. These are the morphologically distinct entities of focal atrophy or post-atrophic hyperplasia (PAH), atypical adenomatous hyperplasia (AAH) or adenosis, and prostatic intraepithelial neoplasia (PIN). The diagnostic criteria of low-and high-grade PIN (LGPIN and HGPIN, respectively) and of lesions suspicious for cancer (LSC) have been established.In the present review, we present the current knowledge about the precursor lesions of prostate cancer. We focus on the epidemiology, pathogenesis, clinical markers, and differential diagnosis of PIN. The similarities between HGPIN and prostate cancer are also discussed. Furthermore, potential markers and management strategies (that is, repeat biopsy, chemoprevention, radical prostatectomy, radiotherapy) are outlined along with updated recommendations." @default.
• W2081363417 created "2016-06-24" @default.
• W2081363417 creator A5007937371 @default.
• W2081363417 creator A5043010453 @default.
• W2081363417 creator A5049857719 @default.
• W2081363417 creator A5051493120 @default.
• W2081363417 date "2007-01-01" @default.
• W2081363417 modified "2023-09-27" @default.
• W2081363417 title "Precursor Lesions of Prostate Cancer" @default.
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