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- W2081403564 endingPage "394" @default.
- W2081403564 startingPage "384" @default.
- W2081403564 abstract "Multiple forms of plasticity are activated following reduced respiratory neural activity. For example, in ventilated rats, a central neural apnea elicits a rebound increase in phrenic and hypoglossal burst amplitude upon resumption of respiratory neural activity, forms of plasticity called inactivity-induced phrenic and hypoglossal motor facilitation (iPMF and iHMF), respectively. Here, we provide a conceptual framework for plasticity following reduced respiratory neural activity to guide future investigations. We review mechanisms giving rise to iPMF and iHMF, present new data suggesting that inactivity-induced plasticity is observed in inspiratory intercostals (iIMF) and point out gaps in our knowledge. We then survey conditions relevant to human health characterized by reduced respiratory neural activity and discuss evidence that inactivity-induced plasticity is elicited during these conditions. Understanding the physiological impact and circumstances in which inactivity-induced respiratory plasticity is elicited may yield novel insights into the treatment of disorders characterized by reductions in respiratory neural activity." @default.
- W2081403564 created "2016-06-24" @default.
- W2081403564 creator A5045479428 @default.
- W2081403564 creator A5052557382 @default.
- W2081403564 creator A5069915171 @default.
- W2081403564 date "2013-11-01" @default.
- W2081403564 modified "2023-09-27" @default.
- W2081403564 title "Inactivity-induced respiratory plasticity: Protecting the drive to breathe in disorders that reduce respiratory neural activity" @default.
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