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• W2081406149 abstract "Apoptosis-inducing nucleosides (AINs) released from CD57( +) HLA-DR(bright) natural suppressor (57.DR-NS) cell line, derived from human decidual tissue, were isolated from 57.DR-NS cell culture supernatant by the combination of thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). Apoptotic cell death was strongly induced in human T cell leukemia Molt4 cells treated with AINs, absolutely depending on DNA strand breaks, with activation of the caspase cascade, especially caspase-3. The administration of AINs to Molt4 tumor-bearing severe combined immunodeficiency (SCID) mice resulted in drastic suppression of tumor growth, with a decrease of tumor size and the appearance of apoptotic signals in tumor tissue. Thus, AINs are candidates for development as anticancer agents." @default.
• W2081406149 created "2016-06-24" @default.
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• W2081406149 date "2000-06-01" @default.
• W2081406149 modified "2023-10-16" @default.
• W2081406149 title "Human T Cell Leukemia Cell Death by Apoptosis-inducing Nucleosides from CD57+HLA-DRbrightNatural Suppressor Cell Line" @default.
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• W2081406149 doi "https://doi.org/10.1111/j.1349-7006.2000.tb00992.x" @default.
• W2081406149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5926391" @default.
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