FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081408258> ?p ?o ?g. }

• W2081408258 endingPage "6879" @default.
• W2081408258 startingPage "6871" @default.
• W2081408258 abstract "Accumulating evidence suggests that the transcriptional activator cAMP response element-binding protein 1 (CREB1) is important for serotonin (5-HT)-induced long-term facilitation (LTF) of the sensorimotor synapse in Aplysia . Moreover, creb1 is among the genes activated by CREB1, suggesting a role for this protein beyond the induction phase of LTF. The time course of the requirement for CREB1 synthesis in the consolidation of long-term facilitation was examined using RNA interference techniques in sensorimotor cocultures. Injection of CREB1 small-interfering RNA (siRNA) immediately or 10 h after 5-HT treatment blocked LTF when measured at 24 and 48 h after treatment. In contrast, CREB1 siRNA did not block LTF when injected 16 h after 5-HT treatment. These results demonstrate that creb1 expression must be sustained for a relatively long time to support the consolidation of LTF. In addition, LTF is also accompanied by a long-term increase in the excitability (LTE) of sensory neurons (SNs). Because LTE was observed in the isolated SN after 5-HT treatment, this long-term change was intrinsic to that element of the circuit. LTE was blocked when CREB1 siRNA was injected into isolated SNs immediately after 5-HT treatment. These data suggest that 5-HT-induced CREB1 synthesis is required for consolidation of both LTF and LTE." @default.
• W2081408258 created "2016-06-24" @default.
• W2081408258 creator A5000304872 @default.
• W2081408258 creator A5045005334 @default.
• W2081408258 creator A5084117702 @default.
• W2081408258 date "2011-05-04" @default.
• W2081408258 modified "2023-09-25" @default.
• W2081408258 title "The Requirement for Enhanced CREB1 Expression in Consolidation of Long-Term Synaptic Facilitation and Long-Term Excitability in Sensory Neurons of<i>Aplysia</i>" @default.
• W2081408258 cites W1625157937 @default.
• W2081408258 cites W1926414151 @default.
• W2081408258 cites W1963628765 @default.
• W2081408258 cites W1964259998 @default.
• W2081408258 cites W1984260356 @default.
• W2081408258 cites W1987030209 @default.
• W2081408258 cites W1989041973 @default.
• W2081408258 cites W1991843519 @default.
• W2081408258 cites W1991869273 @default.
• W2081408258 cites W1995725994 @default.
• W2081408258 cites W2002252799 @default.
• W2081408258 cites W2005304682 @default.
• W2081408258 cites W2011567013 @default.
• W2081408258 cites W2020994883 @default.
• W2081408258 cites W2029712849 @default.
• W2081408258 cites W2032408452 @default.
• W2081408258 cites W2049397044 @default.
• W2081408258 cites W2055829187 @default.
• W2081408258 cites W2057855503 @default.
• W2081408258 cites W2063272496 @default.
• W2081408258 cites W2068412840 @default.
• W2081408258 cites W2071597246 @default.
• W2081408258 cites W2072387005 @default.
• W2081408258 cites W2075856578 @default.
• W2081408258 cites W2080383340 @default.
• W2081408258 cites W2080480553 @default.
• W2081408258 cites W2086156968 @default.
• W2081408258 cites W2087725263 @default.
• W2081408258 cites W2091845852 @default.
• W2081408258 cites W2097650224 @default.
• W2081408258 cites W2103769608 @default.
• W2081408258 cites W2108167859 @default.
• W2081408258 cites W2109363402 @default.
• W2081408258 cites W2112349562 @default.
• W2081408258 cites W2117847158 @default.
• W2081408258 cites W2120173600 @default.
• W2081408258 cites W2123576397 @default.
• W2081408258 cites W2138512713 @default.
• W2081408258 cites W2141674392 @default.
• W2081408258 cites W2144742521 @default.
• W2081408258 cites W2172149172 @default.
• W2081408258 cites W44855071 @default.
• W2081408258 doi "https://doi.org/10.1523/jneurosci.5071-10.2011" @default.
• W2081408258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3092379" @default.
• W2081408258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21543617" @default.
• W2081408258 hasPublicationYear "2011" @default.
• W2081408258 type Work @default.
• W2081408258 sameAs 2081408258 @default.
• W2081408258 citedByCount "54" @default.
• W2081408258 countsByYear W20814082582012 @default.
• W2081408258 countsByYear W20814082582013 @default.
• W2081408258 countsByYear W20814082582014 @default.
• W2081408258 countsByYear W20814082582015 @default.
• W2081408258 countsByYear W20814082582016 @default.
• W2081408258 countsByYear W20814082582017 @default.
• W2081408258 countsByYear W20814082582018 @default.
• W2081408258 countsByYear W20814082582019 @default.
• W2081408258 countsByYear W20814082582020 @default.
• W2081408258 countsByYear W20814082582021 @default.
• W2081408258 countsByYear W20814082582022 @default.
• W2081408258 countsByYear W20814082582023 @default.
• W2081408258 crossrefType "journal-article" @default.
• W2081408258 hasAuthorship W2081408258A5000304872 @default.
• W2081408258 hasAuthorship W2081408258A5045005334 @default.
• W2081408258 hasAuthorship W2081408258A5084117702 @default.
• W2081408258 hasBestOaLocation W20814082581 @default.
• W2081408258 hasConcept C104317684 @default.
• W2081408258 hasConcept C121955636 @default.
• W2081408258 hasConcept C1337776 @default.
• W2081408258 hasConcept C144133560 @default.
• W2081408258 hasConcept C1629964 @default.
• W2081408258 hasConcept C169760540 @default.
• W2081408258 hasConcept C170493617 @default.
• W2081408258 hasConcept C185592680 @default.
• W2081408258 hasConcept C199172495 @default.
• W2081408258 hasConcept C2776014549 @default.
• W2081408258 hasConcept C2778178740 @default.
• W2081408258 hasConcept C55493867 @default.
• W2081408258 hasConcept C86339819 @default.
• W2081408258 hasConcept C86803240 @default.
• W2081408258 hasConcept C88045685 @default.
• W2081408258 hasConcept C95444343 @default.
• W2081408258 hasConceptScore W2081408258C104317684 @default.
• W2081408258 hasConceptScore W2081408258C121955636 @default.
• W2081408258 hasConceptScore W2081408258C1337776 @default.
• W2081408258 hasConceptScore W2081408258C144133560 @default.
• W2081408258 hasConceptScore W2081408258C1629964 @default.
• W2081408258 hasConceptScore W2081408258C169760540 @default.
• W2081408258 hasConceptScore W2081408258C170493617 @default.
• W2081408258 hasConceptScore W2081408258C185592680 @default.

• next