Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081418307> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2081418307 abstract "Cleavage of amyloid precursor protein (APP) by a-and ß-secretases generates soluble proteins known as sAPPa and sAPPß, while Aß42 is a product of the sequential cleavage of APP by ß-, and γ-secretase. Utility of sAPPa and sAPPß as potential predictive and diagnostic markers for neurodegenerative diseases remains ambiguous, as only few and inconsistent results are available. Especially, there are no studies reported on the levels of sAPPa and sAPPß in patients with dementia with Lewy-bodies (DLB) and dementia associated with Parkinson's disease (PDD). To examine the CSF level of sAPPa and sAPPß in patients with AD, DLB, PDD and normal controls (NC), and to explore their clinical and neurochemical correlates. After standardized diagnostic procedures, 107 subjects were included: 50 AD, 23 DLB, 22 PDD and 12 NC. CSF levels of sAPPa and sAPPß and other proteins were determined using commercial multiplex assay kit. Cognition was assessed using MMSE. Non-parametric statistical analyses were used. No significant differences were observed in the levels of sAPPa and sAPPß between the different disease groups. A significant correlation between sAPPß and MMSE score was observed both in the total group (rho 0.38, p < .01), in the AD (rho 0.43, p < .05) and DLB/PDD (rho = 0.37, p < .05) groups, whereas sAPPa correlated with MMSE in the total group only (rho = 0.2, p < .05). Finally, sAPPa and sAPPß levels correlated significantly with Aß38, Aß40, Aß42 Tau and P-Tau281 in the DLB/PDD group, but not in the AD group. CSF sAPPa and sAPPß did not differ between AD, DLB, PDD and NC, but the observed correlation between MMSE score and sAPPß suggests an association with the disease process. The differential association between sAPPa / sAPPß and Aß and tau species in DLB/PDD compared to AD suggests a possible relationship with alpha-synuclein neurodegeneration." @default.
- W2081418307 created "2016-06-24" @default.
- W2081418307 creator A5010755627 @default.
- W2081418307 creator A5010805655 @default.
- W2081418307 creator A5025313057 @default.
- W2081418307 creator A5051934606 @default.
- W2081418307 creator A5079766290 @default.
- W2081418307 creator A5084137341 @default.
- W2081418307 date "2011-07-01" @default.
- W2081418307 modified "2023-10-16" @default.
- W2081418307 title "P2-052: sAPP-α and sApp-β levels in Alzheimer's disease, Lewy body and Parkinson's disease dementia patients and their correlation with clinical diagnosis" @default.
- W2081418307 doi "https://doi.org/10.1016/j.jalz.2011.05.941" @default.
- W2081418307 hasPublicationYear "2011" @default.
- W2081418307 type Work @default.
- W2081418307 sameAs 2081418307 @default.
- W2081418307 citedByCount "0" @default.
- W2081418307 crossrefType "journal-article" @default.
- W2081418307 hasAuthorship W2081418307A5010755627 @default.
- W2081418307 hasAuthorship W2081418307A5010805655 @default.
- W2081418307 hasAuthorship W2081418307A5025313057 @default.
- W2081418307 hasAuthorship W2081418307A5051934606 @default.
- W2081418307 hasAuthorship W2081418307A5079766290 @default.
- W2081418307 hasAuthorship W2081418307A5084137341 @default.
- W2081418307 hasBestOaLocation W20814183071 @default.
- W2081418307 hasConcept C117220453 @default.
- W2081418307 hasConcept C126322002 @default.
- W2081418307 hasConcept C134018914 @default.
- W2081418307 hasConcept C142724271 @default.
- W2081418307 hasConcept C15744967 @default.
- W2081418307 hasConcept C2524010 @default.
- W2081418307 hasConcept C25876315 @default.
- W2081418307 hasConcept C2778548049 @default.
- W2081418307 hasConcept C2779097696 @default.
- W2081418307 hasConcept C2779134260 @default.
- W2081418307 hasConcept C2779483572 @default.
- W2081418307 hasConcept C2779734285 @default.
- W2081418307 hasConcept C31705614 @default.
- W2081418307 hasConcept C33923547 @default.
- W2081418307 hasConcept C502032728 @default.
- W2081418307 hasConcept C71924100 @default.
- W2081418307 hasConcept C90924648 @default.
- W2081418307 hasConceptScore W2081418307C117220453 @default.
- W2081418307 hasConceptScore W2081418307C126322002 @default.
- W2081418307 hasConceptScore W2081418307C134018914 @default.
- W2081418307 hasConceptScore W2081418307C142724271 @default.
- W2081418307 hasConceptScore W2081418307C15744967 @default.
- W2081418307 hasConceptScore W2081418307C2524010 @default.
- W2081418307 hasConceptScore W2081418307C25876315 @default.
- W2081418307 hasConceptScore W2081418307C2778548049 @default.
- W2081418307 hasConceptScore W2081418307C2779097696 @default.
- W2081418307 hasConceptScore W2081418307C2779134260 @default.
- W2081418307 hasConceptScore W2081418307C2779483572 @default.
- W2081418307 hasConceptScore W2081418307C2779734285 @default.
- W2081418307 hasConceptScore W2081418307C31705614 @default.
- W2081418307 hasConceptScore W2081418307C33923547 @default.
- W2081418307 hasConceptScore W2081418307C502032728 @default.
- W2081418307 hasConceptScore W2081418307C71924100 @default.
- W2081418307 hasConceptScore W2081418307C90924648 @default.
- W2081418307 hasIssue "4S_Part_9" @default.
- W2081418307 hasLocation W20814183071 @default.
- W2081418307 hasOpenAccess W2081418307 @default.
- W2081418307 hasPrimaryLocation W20814183071 @default.
- W2081418307 hasRelatedWork W2029029464 @default.
- W2081418307 hasRelatedWork W2029315819 @default.
- W2081418307 hasRelatedWork W2038563492 @default.
- W2081418307 hasRelatedWork W2059242980 @default.
- W2081418307 hasRelatedWork W2071560888 @default.
- W2081418307 hasRelatedWork W2115026925 @default.
- W2081418307 hasRelatedWork W2151958260 @default.
- W2081418307 hasRelatedWork W2657571788 @default.
- W2081418307 hasRelatedWork W2748952813 @default.
- W2081418307 hasRelatedWork W3042900951 @default.
- W2081418307 hasVolume "7" @default.
- W2081418307 isParatext "false" @default.
- W2081418307 isRetracted "false" @default.
- W2081418307 magId "2081418307" @default.
- W2081418307 workType "article" @default.