Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081432938> ?p ?o ?g. }
- W2081432938 endingPage "1629" @default.
- W2081432938 startingPage "1620" @default.
- W2081432938 abstract "The interactions of selenite and tellurite with cytosolic and mitochondrial thioredoxin reductases (TrxR1 and TrxR2) and glutathione reductases (GR) from yeast and mammalian sources were explored. Both TrxR1 and TrxR2 act as selenite and tellurite reductases. Kinetic treatment shows that selenite has a greater affinity than tellurite with both TrxR1 and TrxR2. Considering both k(cat) and K(m), selenite shows a better catalytic efficiency than tellurite with TrxR1, whereas with TrxR2, the catalytic efficiency is similar for both chalcogens. Tellurite is a good substrate for GR, whereas selenite is almost completely ineffective. Selenite or tellurite determine a large mitochondrial permeability transition associated with thiol group oxidation. However, with increasing concentrations of both chalcogens, only about 25% of total thiols are oxidized. In isolated mitochondria, selenite or tellurite per se does not stimulate H₂O₂ production, which, however, is increased by the presence of auranofin. They also determine a large oxidation of mitochondrial pyridine nucleotides. In ovarian cancer cells both chalcogens decrease the mitochondrial membrane potential. These results indicate that selenite and tellurite, interacting with the thiol-dependent enzymes, alter the balance connecting pyridine nucleotides and thiol redox state, consequently leading to mitochondrial and cellular alterations essentially referable to a disulfide stress." @default.
- W2081432938 created "2016-06-24" @default.
- W2081432938 creator A5013793225 @default.
- W2081432938 creator A5021560485 @default.
- W2081432938 creator A5039278410 @default.
- W2081432938 creator A5046780479 @default.
- W2081432938 creator A5061806514 @default.
- W2081432938 creator A5063261026 @default.
- W2081432938 creator A5071887651 @default.
- W2081432938 creator A5074219340 @default.
- W2081432938 creator A5081955287 @default.
- W2081432938 creator A5091347308 @default.
- W2081432938 date "2011-06-01" @default.
- W2081432938 modified "2023-10-16" @default.
- W2081432938 title "Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications" @default.
- W2081432938 cites W119802141 @default.
- W2081432938 cites W1504571050 @default.
- W2081432938 cites W1506043065 @default.
- W2081432938 cites W1592388638 @default.
- W2081432938 cites W1668286863 @default.
- W2081432938 cites W1775749144 @default.
- W2081432938 cites W1972801090 @default.
- W2081432938 cites W1980335366 @default.
- W2081432938 cites W1981345761 @default.
- W2081432938 cites W1990050039 @default.
- W2081432938 cites W1991303607 @default.
- W2081432938 cites W1992390720 @default.
- W2081432938 cites W1992533564 @default.
- W2081432938 cites W1999807929 @default.
- W2081432938 cites W2000925370 @default.
- W2081432938 cites W2003675056 @default.
- W2081432938 cites W2007335557 @default.
- W2081432938 cites W2008820074 @default.
- W2081432938 cites W2010189469 @default.
- W2081432938 cites W2015662414 @default.
- W2081432938 cites W2016375656 @default.
- W2081432938 cites W2018255952 @default.
- W2081432938 cites W2018820860 @default.
- W2081432938 cites W2020420306 @default.
- W2081432938 cites W2032783160 @default.
- W2081432938 cites W2033929467 @default.
- W2081432938 cites W2034207473 @default.
- W2081432938 cites W2041028691 @default.
- W2081432938 cites W2041655473 @default.
- W2081432938 cites W2043427695 @default.
- W2081432938 cites W2048825417 @default.
- W2081432938 cites W2055172401 @default.
- W2081432938 cites W2070884923 @default.
- W2081432938 cites W2081134911 @default.
- W2081432938 cites W2082202554 @default.
- W2081432938 cites W2084004698 @default.
- W2081432938 cites W2084824778 @default.
- W2081432938 cites W2089786617 @default.
- W2081432938 cites W2123730816 @default.
- W2081432938 cites W2135828952 @default.
- W2081432938 cites W2142859704 @default.
- W2081432938 cites W2155800706 @default.
- W2081432938 cites W2163496089 @default.
- W2081432938 cites W2281114779 @default.
- W2081432938 cites W2402688052 @default.
- W2081432938 cites W4240150566 @default.
- W2081432938 cites W4244699956 @default.
- W2081432938 doi "https://doi.org/10.1016/j.freeradbiomed.2011.03.006" @default.
- W2081432938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21397686" @default.
- W2081432938 hasPublicationYear "2011" @default.
- W2081432938 type Work @default.
- W2081432938 sameAs 2081432938 @default.
- W2081432938 citedByCount "22" @default.
- W2081432938 countsByYear W20814329382012 @default.
- W2081432938 countsByYear W20814329382013 @default.
- W2081432938 countsByYear W20814329382014 @default.
- W2081432938 countsByYear W20814329382015 @default.
- W2081432938 countsByYear W20814329382016 @default.
- W2081432938 countsByYear W20814329382017 @default.
- W2081432938 countsByYear W20814329382018 @default.
- W2081432938 countsByYear W20814329382019 @default.
- W2081432938 countsByYear W20814329382022 @default.
- W2081432938 countsByYear W20814329382023 @default.
- W2081432938 crossrefType "journal-article" @default.
- W2081432938 hasAuthorship W2081432938A5013793225 @default.
- W2081432938 hasAuthorship W2081432938A5021560485 @default.
- W2081432938 hasAuthorship W2081432938A5039278410 @default.
- W2081432938 hasAuthorship W2081432938A5046780479 @default.
- W2081432938 hasAuthorship W2081432938A5061806514 @default.
- W2081432938 hasAuthorship W2081432938A5063261026 @default.
- W2081432938 hasAuthorship W2081432938A5071887651 @default.
- W2081432938 hasAuthorship W2081432938A5074219340 @default.
- W2081432938 hasAuthorship W2081432938A5081955287 @default.
- W2081432938 hasAuthorship W2081432938A5091347308 @default.
- W2081432938 hasConcept C158733187 @default.
- W2081432938 hasConcept C178790620 @default.
- W2081432938 hasConcept C179104552 @default.
- W2081432938 hasConcept C181199279 @default.
- W2081432938 hasConcept C185592680 @default.
- W2081432938 hasConcept C203014093 @default.
- W2081432938 hasConcept C2776151105 @default.
- W2081432938 hasConcept C2776243873 @default.
- W2081432938 hasConcept C2777575956 @default.