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- W2081446929 abstract "To investigate the absorption of ginsenosides Rg 1 and Rb 1 in Bazhen Decoction at different intestine segments of rats and the influence of the drug solution concentration, pH, P-gp inhibitor on ones. The intestine cannulation was performed for in situ recirculation. The concentration of ginsenosides Rg 1 and Rb 1 , and phenol red in the flux were measured by the reversed phase HPLC and ultraviolet spectrophotometry, respectively. The absorption of ginsenosides Rg 1 and Rb 1 in Bazhen Decoction in intestine of rat show first-order kinetics with the absorption mechanism of passive diffusion. Ginsenoside Rg 1 has specific absorption locus of duodenum and ginsenoside Rb 1 has specific absorption locus of jejunum. Meanwhile, ginsenoside Rb 1 is the P-gp substrate, and could increase its fraction of bioavailability by corporation with P-gp inhibitor." @default.
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- W2081446929 date "2011-07-01" @default.
- W2081446929 modified "2023-09-27" @default.
- W2081446929 title "Study<i> In Situ</i> on Rat Intestinal Absorption Mechanism and Influential Factors of Ginsenosides Rb1 and Rg1 in Bazhen Decoction" @default.
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- W2081446929 doi "https://doi.org/10.4028/www.scientific.net/amr.282-283.457" @default.
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