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- W2081447071 abstract "In this issue of the journal we are properly reminded, this time by Aldenborg and colleagues in their work Mast Cells and Biogenic Amines in Radiation-induced Pulmonary Fi brosis (1), of the association between mast cells and fibro sis. Indeed, in the skin, increased numbers of mast cells have been observed in keloids, a condition characterized by exces sive deposition of connective tissue, but also during healing in experimental wounds, and Hawkins and associates have clearly documented mast cell hyperplasia in the early in durative phase of progressive systemic sclerosis (sclero derma) (2). In the lung, mast cell hyperplasia has been demonstrated in patients with fibrotic lung disorders (3) and in a number of experimental models of pulmonary fibro sis, including exposure to asbestos, silica, and bleomycin. Clearly, the issue no longer is whether mast cell hyperplasia and fibrosis can concurrently develop but, rather, precisely how are these two events related. Does fibrosis occur as a result of the accumulation of mast cells into the tissue? Alter natively, does the fibrosis and associated inflammation ongo ing in the tissue lead to changes in the microenvironment which promote mast cell development? The short answer to both these questions is that we don't know. Unfortunately, relatively little can be learned from human studies because tissues available for examination represent a snapshot of a complex and dynamic process, and it is more than likely that by the time patients seek medical advice the morbid process has progressed substantially. With respect to studies in ex perimental models, it would be unreasonable, I believe, to conclude anything other than that there appears to be a tem poral parallelism in the evolution of these two events. There is evidence of a direct interaction between mast cells and fibroblasts supporting the notion of a primary role for mast cells in fibrosis. For example, ultrastructural evi dence of mast cell activation and suggestions of a piece meal type of secretion are presented in the study of AI denborg and colleagues, and mast cell-derived products stimulate migration and proliferation of fibroblasts. Also, histamine has been shown to stimulate the growth of fibro blasts both in vitro and in vivo, and cultured fibroblasts can" @default.
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- W2081447071 date "1993-01-01" @default.
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- W2081447071 title "Mast Cells and Fibrosis—Who's on First?" @default.
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- W2081447071 doi "https://doi.org/10.1165/ajrcmb/8.1.7" @default.
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