Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081457536> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2081457536 endingPage "526???532" @default.
- W2081457536 startingPage "526???532" @default.
- W2081457536 abstract "Dopamine is widely used for the treatment of cardiogenic and hypovolemic shock. This study was undertaken to compare the response to dopamine in epicardial conduit coronary arteries of humans, Japanese monkeys, and dogs, and to determine the mechanism of vasoconstriction and vasodilatation. In helical strips of coronary arteries from humans and monkeys partially contracted with prostaglandin F2α, dopamine produced a concentration-related contraction; the human artery contraction was greater. The contractions were reversed to a relaxation by treatment with phentolamine. Relaxation of monkey arteries treated with the a adrenoceptor antagonist was not influenced by metoprolol, a β1 antagonist, or endothelium denudation, but was reversed to contraction by SCH23390, a dopamine1 receptor antagonist. On the other hand, dog coronary arteries responded to dopamine with a relaxation that was abolished by metoprolol, but not influenced by SCH23390 or butoxamine, a β2 antagonist. We conclude that dopamine in clinical doses elicits significant contractions, mediated possibly by a adrenoceptors, in human and monkey coronary arteries; thus, care has to be taken when the amine is used in patients with variant angina pectoris. Relaxation of monkey coronary arteries appears to be associated with activation of dopamine1 receptors, whereas those of the dog arteries are mediated mainly by β1 receptors." @default.
- W2081457536 created "2016-06-24" @default.
- W2081457536 creator A5058142995 @default.
- W2081457536 creator A5063265675 @default.
- W2081457536 creator A5064202288 @default.
- W2081457536 creator A5080526180 @default.
- W2081457536 date "1993-09-01" @default.
- W2081457536 modified "2023-09-24" @default.
- W2081457536 title "Responsiveness to Dopamine of Isolated Epicardial Coronary Arteries from Humans, Monkeys, and Dogs" @default.
- W2081457536 doi "https://doi.org/10.1213/00000539-199309000-00017" @default.
- W2081457536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8396369" @default.
- W2081457536 hasPublicationYear "1993" @default.
- W2081457536 type Work @default.
- W2081457536 sameAs 2081457536 @default.
- W2081457536 citedByCount "6" @default.
- W2081457536 countsByYear W20814575362023 @default.
- W2081457536 crossrefType "journal-article" @default.
- W2081457536 hasAuthorship W2081457536A5058142995 @default.
- W2081457536 hasAuthorship W2081457536A5063265675 @default.
- W2081457536 hasAuthorship W2081457536A5064202288 @default.
- W2081457536 hasAuthorship W2081457536A5080526180 @default.
- W2081457536 hasBestOaLocation W20814575361 @default.
- W2081457536 hasConcept C120770815 @default.
- W2081457536 hasConcept C126322002 @default.
- W2081457536 hasConcept C134018914 @default.
- W2081457536 hasConcept C163415756 @default.
- W2081457536 hasConcept C164705383 @default.
- W2081457536 hasConcept C2776820930 @default.
- W2081457536 hasConcept C2778151854 @default.
- W2081457536 hasConcept C2778742706 @default.
- W2081457536 hasConcept C2779961880 @default.
- W2081457536 hasConcept C2780253649 @default.
- W2081457536 hasConcept C2781280847 @default.
- W2081457536 hasConcept C42219234 @default.
- W2081457536 hasConcept C513476851 @default.
- W2081457536 hasConcept C71924100 @default.
- W2081457536 hasConceptScore W2081457536C120770815 @default.
- W2081457536 hasConceptScore W2081457536C126322002 @default.
- W2081457536 hasConceptScore W2081457536C134018914 @default.
- W2081457536 hasConceptScore W2081457536C163415756 @default.
- W2081457536 hasConceptScore W2081457536C164705383 @default.
- W2081457536 hasConceptScore W2081457536C2776820930 @default.
- W2081457536 hasConceptScore W2081457536C2778151854 @default.
- W2081457536 hasConceptScore W2081457536C2778742706 @default.
- W2081457536 hasConceptScore W2081457536C2779961880 @default.
- W2081457536 hasConceptScore W2081457536C2780253649 @default.
- W2081457536 hasConceptScore W2081457536C2781280847 @default.
- W2081457536 hasConceptScore W2081457536C42219234 @default.
- W2081457536 hasConceptScore W2081457536C513476851 @default.
- W2081457536 hasConceptScore W2081457536C71924100 @default.
- W2081457536 hasIssue "3" @default.
- W2081457536 hasLocation W20814575361 @default.
- W2081457536 hasLocation W20814575362 @default.
- W2081457536 hasLocation W20814575363 @default.
- W2081457536 hasOpenAccess W2081457536 @default.
- W2081457536 hasPrimaryLocation W20814575361 @default.
- W2081457536 hasRelatedWork W1978500043 @default.
- W2081457536 hasRelatedWork W2048859483 @default.
- W2081457536 hasRelatedWork W2057537203 @default.
- W2081457536 hasRelatedWork W2077502198 @default.
- W2081457536 hasRelatedWork W2081457536 @default.
- W2081457536 hasRelatedWork W2093919627 @default.
- W2081457536 hasRelatedWork W2111010342 @default.
- W2081457536 hasRelatedWork W2113424951 @default.
- W2081457536 hasRelatedWork W2135033561 @default.
- W2081457536 hasRelatedWork W2411830643 @default.
- W2081457536 hasVolume "77" @default.
- W2081457536 isParatext "false" @default.
- W2081457536 isRetracted "false" @default.
- W2081457536 magId "2081457536" @default.
- W2081457536 workType "article" @default.