Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081459547> ?p ?o ?g. }
- W2081459547 endingPage "1304" @default.
- W2081459547 startingPage "1295" @default.
- W2081459547 abstract "Present study reports synthesis and characterization of an enzymatically crosslinked injectable gel (iGel) suitable for cell based bone tissue engineering application. The gel comprises of carboxymethyl–chitosan (CMC)/gelatin/nano-hydroxyapatite (nHAp) susceptible to tyrosinase/p-cresol mediated in situ gelling at physiological temperature. Study revealed that a combination of tyrosinase (60U) and p-cresol (2 mM) as crosslinking agents yield rigid gels at physiological temperature when applied to CMC/gelatin within 35 min in presence or absence of nHAp. Rheological study in conjugation with FT-IR analysis showed that an increase in CMC concentration in the gel leads to higher degree of crosslinking and higher strength. Scanning electron microscopy showed that pore sizes of iGels increased with higher gelatin concentration. In vitro study of osteoblast cell proliferation and differentiation showed that, although all iGels are supportive towards the growth of primary osteoblast cells, GC1:1 supported cellular differentiation to the maximum. Application of iGels in mice revealed that stability of the in situ formed gels depends on the degree of crosslinking and CMC concentration. In conclusion, the iGels may be used in treating irregular small bone defects with minimal clinical invasion as well as for bone cell delivery." @default.
- W2081459547 created "2016-06-24" @default.
- W2081459547 creator A5004710773 @default.
- W2081459547 creator A5035654430 @default.
- W2081459547 creator A5039944092 @default.
- W2081459547 creator A5046111170 @default.
- W2081459547 creator A5055574140 @default.
- W2081459547 creator A5078392753 @default.
- W2081459547 date "2011-10-01" @default.
- W2081459547 modified "2023-10-12" @default.
- W2081459547 title "Enzymatically crosslinked carboxymethyl–chitosan/gelatin/nano-hydroxyapatite injectable gels for in situ bone tissue engineering application" @default.
- W2081459547 cites W1574631190 @default.
- W2081459547 cites W1648905043 @default.
- W2081459547 cites W1969136202 @default.
- W2081459547 cites W1970778553 @default.
- W2081459547 cites W1971669047 @default.
- W2081459547 cites W1975656702 @default.
- W2081459547 cites W1978351659 @default.
- W2081459547 cites W1982769493 @default.
- W2081459547 cites W1983509147 @default.
- W2081459547 cites W1987190449 @default.
- W2081459547 cites W1988024075 @default.
- W2081459547 cites W1999318759 @default.
- W2081459547 cites W2004574648 @default.
- W2081459547 cites W2005308102 @default.
- W2081459547 cites W2013127210 @default.
- W2081459547 cites W2018595771 @default.
- W2081459547 cites W2026607816 @default.
- W2081459547 cites W2033715726 @default.
- W2081459547 cites W2037070758 @default.
- W2081459547 cites W2038430090 @default.
- W2081459547 cites W2042947066 @default.
- W2081459547 cites W2045383620 @default.
- W2081459547 cites W2047292103 @default.
- W2081459547 cites W2048381378 @default.
- W2081459547 cites W2050911192 @default.
- W2081459547 cites W2053299040 @default.
- W2081459547 cites W2055476008 @default.
- W2081459547 cites W2061001156 @default.
- W2081459547 cites W2064600837 @default.
- W2081459547 cites W2066297022 @default.
- W2081459547 cites W2068705727 @default.
- W2081459547 cites W2070338617 @default.
- W2081459547 cites W2074794805 @default.
- W2081459547 cites W2076358165 @default.
- W2081459547 cites W2077485813 @default.
- W2081459547 cites W2078267560 @default.
- W2081459547 cites W2086361550 @default.
- W2081459547 cites W2088650104 @default.
- W2081459547 cites W2088693043 @default.
- W2081459547 cites W2091800170 @default.
- W2081459547 cites W2094205689 @default.
- W2081459547 cites W2095478554 @default.
- W2081459547 cites W2096136468 @default.
- W2081459547 cites W2114126007 @default.
- W2081459547 cites W2125364971 @default.
- W2081459547 cites W2133416728 @default.
- W2081459547 cites W2133819222 @default.
- W2081459547 cites W2153268483 @default.
- W2081459547 cites W2170514092 @default.
- W2081459547 cites W2171412229 @default.
- W2081459547 cites W3099601071 @default.
- W2081459547 doi "https://doi.org/10.1016/j.msec.2011.04.007" @default.
- W2081459547 hasPublicationYear "2011" @default.
- W2081459547 type Work @default.
- W2081459547 sameAs 2081459547 @default.
- W2081459547 citedByCount "100" @default.
- W2081459547 countsByYear W20814595472012 @default.
- W2081459547 countsByYear W20814595472013 @default.
- W2081459547 countsByYear W20814595472014 @default.
- W2081459547 countsByYear W20814595472015 @default.
- W2081459547 countsByYear W20814595472016 @default.
- W2081459547 countsByYear W20814595472017 @default.
- W2081459547 countsByYear W20814595472018 @default.
- W2081459547 countsByYear W20814595472019 @default.
- W2081459547 countsByYear W20814595472020 @default.
- W2081459547 countsByYear W20814595472021 @default.
- W2081459547 countsByYear W20814595472022 @default.
- W2081459547 countsByYear W20814595472023 @default.
- W2081459547 crossrefType "journal-article" @default.
- W2081459547 hasAuthorship W2081459547A5004710773 @default.
- W2081459547 hasAuthorship W2081459547A5035654430 @default.
- W2081459547 hasAuthorship W2081459547A5039944092 @default.
- W2081459547 hasAuthorship W2081459547A5046111170 @default.
- W2081459547 hasAuthorship W2081459547A5055574140 @default.
- W2081459547 hasAuthorship W2081459547A5078392753 @default.
- W2081459547 hasBestOaLocation W20814595471 @default.
- W2081459547 hasConcept C127413603 @default.
- W2081459547 hasConcept C136229726 @default.
- W2081459547 hasConcept C13965031 @default.
- W2081459547 hasConcept C185592680 @default.
- W2081459547 hasConcept C188027245 @default.
- W2081459547 hasConcept C192562407 @default.
- W2081459547 hasConcept C202751555 @default.
- W2081459547 hasConcept C2778260815 @default.
- W2081459547 hasConcept C2778823387 @default.
- W2081459547 hasConcept C2779732960 @default.
- W2081459547 hasConcept C42360764 @default.