FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081465102> ?p ?o ?g. }

• W2081465102 endingPage "E240" @default.
• W2081465102 startingPage "E233" @default.
• W2081465102 abstract "Elevation of plasma lactate levels induces peripheral insulin resistance, but the underlying mechanisms are unclear. We examined whether lactate infusion in rats suppresses glycolysis preceding insulin resistance and whether lactate-induced insulin resistance is accompanied by altered insulin signaling and/or insulin-stimulated glucose transport in skeletal muscle. Hyperinsulinemic euglycemic clamps were conducted for 6 h in conscious, overnight-fasted rats with or without lactate infusion (120 micromol x kg(-1) x min(-1)) during the final 3.5 h. Lactate infusion increased plasma lactate levels about fourfold. The elevation of plasma lactate had rapid effects to suppress insulin-stimulated glycolysis, which clearly preceded its effect to decrease insulin-stimulated glucose uptake. Both submaximal and maximal insulin-stimulated glucose transport decreased 25-30% (P < 0.05) in soleus but not in epitrochlearis muscles of lactate-infused rats. Lactate infusion did not alter insulin's ability to phosphorylate the insulin receptor, the insulin receptor substrate (IRS)-1, or IRS-2 but decreased insulin's ability to stimulate IRS-1- and IRS-2-associated phosphatidylinositol 3-kinase activities and Akt/protein kinase B activity by 47, 75, and 55%, respectively (P < 0.05 for all). In conclusion, elevation of plasma lactate suppressed glycolysis before its effect on insulin-stimulated glucose uptake, consistent with the hypothesis that suppression of glucose metabolism could precede and cause insulin resistance. In addition, lactate-induced insulin resistance was associated with impaired insulin signaling and decreased insulin-stimulated glucose transport in skeletal muscle." @default.
• W2081465102 created "2016-06-24" @default.
• W2081465102 creator A5005596774 @default.
• W2081465102 creator A5010305620 @default.
• W2081465102 creator A5011853620 @default.
• W2081465102 creator A5041825735 @default.
• W2081465102 creator A5046219540 @default.
• W2081465102 creator A5070694339 @default.
• W2081465102 date "2002-08-01" @default.
• W2081465102 modified "2023-09-26" @default.
• W2081465102 title "Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling" @default.
• W2081465102 cites W1417669828 @default.
• W2081465102 cites W1877856201 @default.
• W2081465102 cites W1943009833 @default.
• W2081465102 cites W1946872534 @default.
• W2081465102 cites W1974540301 @default.
• W2081465102 cites W1994050387 @default.
• W2081465102 cites W1999755935 @default.
• W2081465102 cites W2029218110 @default.
• W2081465102 cites W2041249629 @default.
• W2081465102 cites W2041646729 @default.
• W2081465102 cites W2043106623 @default.
• W2081465102 cites W2048109379 @default.
• W2081465102 cites W2075171810 @default.
• W2081465102 cites W2083262799 @default.
• W2081465102 cites W2089582113 @default.
• W2081465102 cites W2091034365 @default.
• W2081465102 cites W2104848153 @default.
• W2081465102 cites W2106490583 @default.
• W2081465102 cites W2120246954 @default.
• W2081465102 cites W2122460963 @default.
• W2081465102 cites W2123167115 @default.
• W2081465102 cites W2125026523 @default.
• W2081465102 cites W2133137979 @default.
• W2081465102 cites W2133550632 @default.
• W2081465102 cites W2134085260 @default.
• W2081465102 cites W2137953722 @default.
• W2081465102 cites W2149860530 @default.
• W2081465102 cites W2155875957 @default.
• W2081465102 cites W2161830398 @default.
• W2081465102 cites W2166838876 @default.
• W2081465102 cites W2170537843 @default.
• W2081465102 cites W2196957880 @default.
• W2081465102 cites W2214654003 @default.
• W2081465102 cites W2272294448 @default.
• W2081465102 cites W2284728114 @default.
• W2081465102 cites W2437989670 @default.
• W2081465102 doi "https://doi.org/10.1152/ajpendo.00557.2001" @default.
• W2081465102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12110527" @default.
• W2081465102 hasPublicationYear "2002" @default.
• W2081465102 type Work @default.
• W2081465102 sameAs 2081465102 @default.
• W2081465102 citedByCount "106" @default.
• W2081465102 countsByYear W20814651022012 @default.
• W2081465102 countsByYear W20814651022013 @default.
• W2081465102 countsByYear W20814651022014 @default.
• W2081465102 countsByYear W20814651022015 @default.
• W2081465102 countsByYear W20814651022016 @default.
• W2081465102 countsByYear W20814651022017 @default.
• W2081465102 countsByYear W20814651022018 @default.
• W2081465102 countsByYear W20814651022019 @default.
• W2081465102 countsByYear W20814651022020 @default.
• W2081465102 countsByYear W20814651022021 @default.
• W2081465102 countsByYear W20814651022022 @default.
• W2081465102 countsByYear W20814651022023 @default.
• W2081465102 crossrefType "journal-article" @default.
• W2081465102 hasAuthorship W2081465102A5005596774 @default.
• W2081465102 hasAuthorship W2081465102A5010305620 @default.
• W2081465102 hasAuthorship W2081465102A5011853620 @default.
• W2081465102 hasAuthorship W2081465102A5041825735 @default.
• W2081465102 hasAuthorship W2081465102A5046219540 @default.
• W2081465102 hasAuthorship W2081465102A5070694339 @default.
• W2081465102 hasConcept C112446052 @default.
• W2081465102 hasConcept C126322002 @default.
• W2081465102 hasConcept C134018914 @default.
• W2081465102 hasConcept C17093226 @default.
• W2081465102 hasConcept C185592680 @default.
• W2081465102 hasConcept C20251656 @default.
• W2081465102 hasConcept C2777391703 @default.
• W2081465102 hasConcept C2777866211 @default.
• W2081465102 hasConcept C2779306644 @default.
• W2081465102 hasConcept C2779959927 @default.
• W2081465102 hasConcept C55493867 @default.
• W2081465102 hasConcept C62231903 @default.
• W2081465102 hasConcept C62478195 @default.
• W2081465102 hasConcept C71924100 @default.
• W2081465102 hasConcept C75217442 @default.
• W2081465102 hasConcept C86803240 @default.
• W2081465102 hasConceptScore W2081465102C112446052 @default.
• W2081465102 hasConceptScore W2081465102C126322002 @default.
• W2081465102 hasConceptScore W2081465102C134018914 @default.
• W2081465102 hasConceptScore W2081465102C17093226 @default.
• W2081465102 hasConceptScore W2081465102C185592680 @default.
• W2081465102 hasConceptScore W2081465102C20251656 @default.
• W2081465102 hasConceptScore W2081465102C2777391703 @default.
• W2081465102 hasConceptScore W2081465102C2777866211 @default.
• W2081465102 hasConceptScore W2081465102C2779306644 @default.
• W2081465102 hasConceptScore W2081465102C2779959927 @default.

• next