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• W2081471150 abstract "The effects of intra-arterial vasopressin upon canine hepatic arterial blood flow were investigated to determine the possible ischemic hazard to the liver by this agent when utilized for the clinical control of gastrointestinal hemorrhage. Blood flow was measured with an electromagnetic flowmeter; arterial and portal venous pressures were recorded. Unstimulated hepatic arterial blood flow was 294 ± 32 (SE) ml min−1 in eight animals. Arterial pressure was 126 ± 3 mm Hg and portal venous pressure was 8.4 ± 1.0 mm Hg. Calculated hepatic arterial resistance was 0.493 ± 0.080 peripheral resistance units (PRU). When injected in concentrations ranging logarithmically from 5 × 10−5 to 5 × 10−2 units kg−1, vasopressin produced a dose-dependent diminution in flow. At the highest concentration, vasopressin reduced flow by 199 ± 43 ml min−1 and increased aortic pressure by 13 ± 2 mm Hg. This same concentration of vasopressin reduced portal venous pressure by 1.8 ± 0.2 mm Hg. When infused, intraarterially, at a concentration of 5 × 10−3 units kg−1 min−1, vasopressin produced a prompt reduction in flow to 206 ± 30 ml min−1, within 1 min, following which, flow gradually returned to control, and at the fifth minute the value, 258 ± 24 ml min−1, was not significantly different from control. During this infusion, arterial pressure increased by 10 mm Hg at the sixth minute and remained elevated throughout the infusion. This same concentration of vasopressin reduced portal venous pressure to 6.0 ± 0.9 mm Hg at the ninth minute of the infusion. These observations in dogs indicate that vasopressin is a potent constrictor of the hepatic artery, when administered intra-arterially; however, this vasoconstrictor effect is a transient one and, in fact, infusions of this agent cause constriction characterized by autoregulatory escape, promptly restoring the arterial flow to control values within minutes. Assuming that man's hepatic artery will respond in a similar fashion, these observations suggest that the clinical use of vasopressin to control upper gastrointestinal bleeding in man is unlikely to pose any threat of significant ischemia to his liver, as has been suggested in the past." @default.
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• W2081471150 date "1977-09-01" @default.
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• W2081471150 title "Vasopressin and canine hepatic arterial blood flow" @default.
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• W2081471150 doi "https://doi.org/10.1016/0022-4804(77)90016-6" @default.
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