Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081471836> ?p ?o ?g. }
- W2081471836 endingPage "12" @default.
- W2081471836 startingPage "1" @default.
- W2081471836 abstract "Thrombospondin-1 (TSP-1) is a matricellular glycoprotein that influences cellular phenotype and the structure of the extracellular matrix. These effects are important components of the tissue remodeling that is associated with angiogenesis and neoplasia. The genetic mutations in oncogenes and tumor suppressor genes that occur within tumor cells are frequently associated with decreased expression of TSP-1. However, the TSP-1 that is produced by stromal fibroblasts, endothelial cells and immune cells suppresses tumor progression. TSP-1 inhibits angiogenesis through direct effects on endothelial cell migration and survival and through indirect effects on growth factor mobilization. TSP-1 that is present in the tumor microenvironment also acts to suppress tumor cell growth through activation of transforming growth factor β in those tumor cells that are responsive to TGFβ. In this review, the molecular basis for the role of TSP-1 in the inhibition of tumor growth and angiogenesis is summarized." @default.
- W2081471836 created "2016-06-24" @default.
- W2081471836 creator A5083192393 @default.
- W2081471836 date "2002-01-01" @default.
- W2081471836 modified "2023-09-30" @default.
- W2081471836 title "Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth" @default.
- W2081471836 cites W1502685532 @default.
- W2081471836 cites W1522549867 @default.
- W2081471836 cites W1543486305 @default.
- W2081471836 cites W1549631663 @default.
- W2081471836 cites W1554296669 @default.
- W2081471836 cites W1596384556 @default.
- W2081471836 cites W1605580017 @default.
- W2081471836 cites W1670509675 @default.
- W2081471836 cites W1832925227 @default.
- W2081471836 cites W1941829554 @default.
- W2081471836 cites W1946162597 @default.
- W2081471836 cites W1969065141 @default.
- W2081471836 cites W1977366543 @default.
- W2081471836 cites W1978202313 @default.
- W2081471836 cites W1980280003 @default.
- W2081471836 cites W1983956381 @default.
- W2081471836 cites W1985048556 @default.
- W2081471836 cites W1992203722 @default.
- W2081471836 cites W1996108441 @default.
- W2081471836 cites W1997693327 @default.
- W2081471836 cites W1998225655 @default.
- W2081471836 cites W1998320552 @default.
- W2081471836 cites W1998596090 @default.
- W2081471836 cites W2007799501 @default.
- W2081471836 cites W2014771072 @default.
- W2081471836 cites W2016068460 @default.
- W2081471836 cites W2016391435 @default.
- W2081471836 cites W2018069344 @default.
- W2081471836 cites W2022665089 @default.
- W2081471836 cites W2025406290 @default.
- W2081471836 cites W2029002186 @default.
- W2081471836 cites W2032511198 @default.
- W2081471836 cites W2050429474 @default.
- W2081471836 cites W2055515174 @default.
- W2081471836 cites W2055843476 @default.
- W2081471836 cites W2059940674 @default.
- W2081471836 cites W2060211925 @default.
- W2081471836 cites W2065730608 @default.
- W2081471836 cites W2070742907 @default.
- W2081471836 cites W2072890248 @default.
- W2081471836 cites W2074995350 @default.
- W2081471836 cites W2077443612 @default.
- W2081471836 cites W2078247661 @default.
- W2081471836 cites W2083283637 @default.
- W2081471836 cites W2084747730 @default.
- W2081471836 cites W2085777866 @default.
- W2081471836 cites W2085939705 @default.
- W2081471836 cites W2087749727 @default.
- W2081471836 cites W2090346571 @default.
- W2081471836 cites W2094619101 @default.
- W2081471836 cites W2095315716 @default.
- W2081471836 cites W2100577875 @default.
- W2081471836 cites W2101650166 @default.
- W2081471836 cites W2114900551 @default.
- W2081471836 cites W2118841182 @default.
- W2081471836 cites W2125497603 @default.
- W2081471836 cites W2126001489 @default.
- W2081471836 cites W2127230663 @default.
- W2081471836 cites W2131245889 @default.
- W2081471836 cites W2131762447 @default.
- W2081471836 cites W2132318673 @default.
- W2081471836 cites W2134674686 @default.
- W2081471836 cites W2138423846 @default.
- W2081471836 cites W2149360108 @default.
- W2081471836 cites W2162838387 @default.
- W2081471836 cites W2224266189 @default.
- W2081471836 cites W2344589255 @default.
- W2081471836 cites W4241071299 @default.
- W2081471836 cites W4241980056 @default.
- W2081471836 doi "https://doi.org/10.1111/j.1582-4934.2002.tb00307.x" @default.
- W2081471836 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6740251" @default.
- W2081471836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12003665" @default.
- W2081471836 hasPublicationYear "2002" @default.
- W2081471836 type Work @default.
- W2081471836 sameAs 2081471836 @default.
- W2081471836 citedByCount "490" @default.
- W2081471836 countsByYear W20814718362012 @default.
- W2081471836 countsByYear W20814718362013 @default.
- W2081471836 countsByYear W20814718362014 @default.
- W2081471836 countsByYear W20814718362015 @default.
- W2081471836 countsByYear W20814718362016 @default.
- W2081471836 countsByYear W20814718362017 @default.
- W2081471836 countsByYear W20814718362018 @default.
- W2081471836 countsByYear W20814718362019 @default.
- W2081471836 countsByYear W20814718362020 @default.
- W2081471836 countsByYear W20814718362021 @default.
- W2081471836 countsByYear W20814718362022 @default.
- W2081471836 countsByYear W20814718362023 @default.
- W2081471836 crossrefType "journal-article" @default.
- W2081471836 hasAuthorship W2081471836A5083192393 @default.
- W2081471836 hasBestOaLocation W20814718362 @default.
- W2081471836 hasConcept C109523444 @default.