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- W2081479672 abstract "Regulation of the immune system is fundamental for proper immune function and homeostasis. In the periphery, regulatory T cells provide self-tolerance and protect the host from harmful autoreactive T cells. Regulatory T cells are also involved in the pathogenesis of chronic viral infectious diseases and cancer. Both the CD4(+) and the CD8(+) T cell compartments contain regulatory T cells. Although various CD4(+) regulatory T-cell subsets represent the best characterized regulatory T-cell populations, CD8(+) regulatory T cells also have strong immunosuppressive properties and are involved in the pathogenesis of various clinical conditions. In this review, we will discuss the phenotypic and functional characteristics of CD8(+) regulatory T cells in comparison to CD4(+) regulatory T cells." @default.
- W2081479672 created "2016-06-24" @default.
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- W2081479672 creator A5042862730 @default.
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- W2081479672 date "2008-11-01" @default.
- W2081479672 modified "2023-10-01" @default.
- W2081479672 title "CD8+ regulatory T cells—A distinct T-cell lineage or a transient T-cell phenotype?" @default.
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- W2081479672 doi "https://doi.org/10.1016/j.humimm.2008.08.291" @default.
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