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- W2081488678 abstract "Abstract Stereospecific binding sites for (−)-[ 3 H]dihydroalprenolol, a β-adrenergic antagonist, have been identified in guinea-pig myocardial cell membranes and lung tissue preparations. A close correlation between the abilities of β-adrenergic antagonists to compete with labelled antagonist binding and to block the response of isoproterenol plus Gpp(NH)p† stimulated adenylate cyclase has been found. Equilibrium binding of (−)-[ 3 H]dihydroalprenolol to binding sites of cardiac and lung tissue displays characteristics consistent with negative cooperativity among the DHA binding sites: Scatchard plots are curvilinear with upward concavity. The existence of site-site interactions of the negatively cooperative type was demonstrated directly by the ability of unlabelled (−)alprenolol to accelerate the dissociation of (−)-¦ 3 H¦dihydroalprenolol under conditions where rebinding of the radioligand does not occur." @default.
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- W2081488678 date "1979-10-01" @default.
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- W2081488678 title "Evidence for negative cooperativity among β-adrenergic receptors in cardiac and lung tissue of guinea pig" @default.
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- W2081488678 doi "https://doi.org/10.1016/0006-2952(79)90600-2" @default.
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